ArticleProbiotics and antimicrobial proteins2026
Trp-containing Peptides with Therapeutic Potential for Cutibacterium acnes Infection.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Effect of Fatty Acid Chain Modification on the Self-Assembly Behavior and Antimicrobial Activity of Antimicrobial Peptides.Antibiotics (Basel, Switzerland) · 2026Article
- Physicochemical Characteristics of Amphipathic Peptides and Their Cytotoxic Effects on Cancer and Normal Cell Lines.International journal of molecular sciences · 2026Article
- Lyophilized Cell-Free Supernatants ofLife (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cutibacterium acnes (C. acnes, formerly classified as Propionibacterium acnes) is a Gram-positive bacterium that contributes to the development of acne vulgaris, resulting in inflammation and pustule formation on the skin. In this study, we developed and synthesized a series of antimicrobial peptides (AMPs) that are derived from the skin secretion of Rana chensinensis. Screening by MIC assay, Trp-containing peptides had potent anti-bacterial activity against C. acnes. The effect of Trp-containing peptides on the morphology was detected by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The cell surface of C. acnes that was treated with Trp-containing peptides appeared rough and irregular. Further investigations into the peptides effects on cell membranes were conducted via zeta potential, Disc3(5) and Live/Dead assays. The results revealed that the AMPs bound to the cell surface, induced the disruption of the cell membranes and ultimately led to cell death. The leakage of cellular contents like nucleic acid, K
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Registered trials
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