SynthesisCancer metastasis reviews2025
Demystifying the link between periodontitis and oral cancer: a systematic review integrating clinical, pre-clinical, and in vitro data.
Synthesis in Cancer metastasis reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Periodontitis as a Modulator of Malignant Transformation in Oral Potentially Malignant Disorders: A Narrative Review of Biological Mechanisms and Clinical Implications.Current oncology reports · 2026Review
- The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis.Clinical and experimental dental research · 2026Review
- Review
- Porphyromonas gingivalis promotes oral squamous cell carcinoma progression via the IL-6/EZH2/Snai2 axis.Scientific reports · 2026Article
- The Mediating Role of Patient Activation in the Association Between Illness Perception and Self-Management Behavior Among Patients with Oral Cancer.Patient preference and adherence · 2026Article
- Clinical and laboratory biomarker correlates of lip, oral cavity, and pharyngeal cancer status in a large retrospective clinical database.Frontiers in oral health · 2026Article
- The microbiome-inflammation-immune axis in oral squamous cell carcinoma: from mechanistic insights to therapeutic perspectives.Frontiers in immunology · 2026Review
- Genetic and Epigenetic Biomarkers for the Early Oral Cancerization Risk in Periodontitis Patients.Current issues in molecular biology · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Chronic inflammation and microbial dysbiosis have been implicated in the development of head and neck squamous cell carcinoma (HNSCC), particularly oral cavity squamous cell carcinoma (OSCC). Periodontitis is a common chronic inflammatory disease characterized by the progressive destruction of tooth-supporting structures. While periodontitis Has been associated with an increased risk of OSCC in epidemiological and mechanistic studies, the strength of this association is unclear. This systematic review and meta-analysis aimed to clarify this relationship by synthesizing current evidence, including potential biological mechanisms. A comprehensive search strategy was implemented across five databases to identify relevant publications up to June 2025. Eligible studies had human, in vitro, or animal data that evaluated the association between periodontitis and OSCC. A meta-analysis was conducted to assess the association between periodontitis and OSCC. From 6,992 records identified, 116 studies were included in the systematic review, and 26 were eligible for meta-analysis. The meta-analysis supports an association between both clinically assessed and self-reported periodontitis and an increased risk of OSCC, with similar associations observed for HNSCC overall. These clinical associations are supported by experimental evidence demonstrating that key periodontal pathogens, such as Porphyromonas gingivalis and Fusobacterium nucleatum, contribute to OSCC progression through mechanisms involving inflammation, epithelial-to-mesenchymal transition (EMT), and immune evasion. In conclusion, although epidemiological and mechanistic studies discussed in this review provide evidence of an association between periodontitis and OSCC, future studies using standardized diagnostic criteria, robust design, and clinically relevant experimental models are essential for causal inferences and to deepen knowledge of underlying mechanisms.
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