Evidence map›Paper›PMID 40924281›Full record

ArticleWiener medizinische Wochenschrift (1946)2026

Rosai-Dorfman disease mimicking IgG4-related disease.

Okan Cetin, Sertac Yetisir, Timur Selcuk Akpinar, Gülcin Yegen, Mustafa Altinkaynak

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Article in Wiener medizinische Wochenschrift (1946), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Okan CetinDepartment of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34093, Istanbul, Turkey. okancetin@istanbul.edu.tr.ORCID http://orcid.org/0000-0003-1672-4743
Sertac YetisirDepartment of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34093, Istanbul, Turkey.
Timur Selcuk AkpinarDepartment of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34093, Istanbul, Turkey.
Gülcin YegenDepartment of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Mustafa AltinkaynakDepartment of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34093, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rosai-Dorfman disease (RDD) is a rare histiocytic disorder that may clinically and histologically resemble IgG4-related disease (IgG4-RD), especially in the presence of IgG4-positive plasma cell infiltration. In this case, a 69-year-old woman with generalized lymphadenopathy, constitutional symptoms, and elevated IgG4 levels was initially suspected to have IgG4-RD based on core needle biopsy. However, further evaluation with excisional lymph node biopsy revealed emperipolesis and S100-positive histiocytes, confirming the diagnosis of RDD. This case illustrates the diagnostic challenge of differentiating RDD from IgG4-RD, given the overlap in both clinical presentation and histopathological features, and highlights the importance of excisional biopsy combined with careful clinical evaluation to ensure an accurate diagnosis and appropriate management.

Indexed as

Histiocytosis, SinusImmunoglobulin GImmunoglobulin G4-Related DiseaseAgedDiagnosis, DifferentialEmperipolesisFemaleHistiocytesHumansLymph NodesPlasma CellsImmunoglobulin GB symptomsHistiocytic disorderIgG4-related diseaseMassive lymphadenopathyRosai–Dorfman disease

Identifiers

PMID40924281

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.