Efficacy of sonothrombolysis as an adjunct to primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: a systematic review and meta-analysis.

Mohamed Abo Zeid, Ahmed Farid Gadelmawla, Kareem Khalefa, Ahmed Yasser Shaban

Abstract readSystematic ReviewMeta-Analysis

In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Enhancement of content, purity and anti-myocardial ischemia-reperfusion injury activity of persimmon leaf flavonoids: Ultrasonic-assisted extraction, purification and related mechanism.Ultrasonics sonochemistry · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohamed Abo ZeidFaculty of Medicine, Tanta University, Tanta, Egypt.

Ahmed Farid GadelmawlaFaculty of Medicine, Menoufia University, Menoufia, Egypt.

Kareem KhalefaFaculty of Medicine, Tanta University, Tanta, Egypt. karim_31059617@med.tanta.edu.eg.ORCID http://orcid.org/0009-0006-1037-9095

Ahmed Yasser ShabanFaculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review, we aimed to evaluate Sonothrombolysis when combined with primary percutaneous coronary intervention (pPCI) in STEMI patients with regard to improving cardiac function and clinical outcomes. This study primarily assesses short-term efficacy outcomes, while long-term impacts, such as mortality, were not evaluated. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we searched four electronic databases (PubMed, Scopus, Cochrane Library, and Web of Science) to identify eligible studies reported up to November 2024. Four studies, with a total population of 252 participants, were included. The sonothrombolysis group demonstrated an overall greater improvement in left ventricular ejection fraction compared to the control group (MD = 3.07, 95% CI [1.20 to 4.94], p = 0.001), with no heterogeneity (p = 0.44, I

Indexed as

Percutaneous Coronary InterventionST Elevation Myocardial InfarctionUltrasonic TherapyCombined Modality TherapyHumansStroke VolumeTreatment OutcomeVentricular Function, LeftMyocardial infarctionMyocardial ischemiapPCISonothrombolysisSTEMIUltrasound-enhanced thrombolysis

Identifiers

PMID40924279

DOI10.1007/s11239-025-03176-1

PMCPMC13018063

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.