ArticleJournal of clinical monitoring and computing2026
Evaluation of the Analgesia Nociception Index (ANI) as an indicator of discomfort in deeply sedated, prepubescent patients.
Article in Journal of clinical monitoring and computing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04913038 (Assessment of the Validity of the ANI in Children Over 2 Years of Age and Prepubescent Ventilated and Sedated in Pediatric Intensive Care.), which is not on this map. Cited by 1 paper.
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Assessment of the Validity of the ANI in Children Over 2 Years of Age and Prepubescent Ventilated and Sedated in Pediatric Intensive Care.
Who cites it
1 citing paper in PubMed.
- Heart rate variability as a marker of multiple organ dysfunction syndrome in deeply sedated, prepubescent patients: a secondary analysis.Journal of clinical monitoring and computing · 2026Observational
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The Analgesia Nociception Index (ANI) has been used to assess discomfort in anesthetized adults. The COMFORT Behavior Scale (CBS) is recommended for assessing discomfort in intubated and sedated children. The primary objective of the present study was to assess the validity and performance of the ANI as an indicator of discomfort in intubated, ventilated children in a pediatric intensive care unit (PICU). A prospective, non-interventional, single-center pilot study was conducted between June 1st, 2021, and November 31st, 2023. Intubated, sedated, prepubescent patients aged between 2 and 10 years (for girls) or between 2 and 12 years (for boys) were included. The instantaneous ANI (ANIi) and the mean ANI (ANIm) were recorded continuously during care procedures. Data were analyzed before (period (P)1), during (P2) and after (P3) care procedures. 50 patients were included; the median (interquartile range [IQR]) age was 7 [4; 9] years. The ANIi decreased significantly between P1 and P2 (median [IQR]: 59 [45; 80] vs. 33 [26; 42], respectively; p < 0.0001) and increased significantly between P2 and P3 (33 [26; 42] vs. 51 [33; 72], respectively; p < 0.0001). The CBS score increased significantly between P2 and P3 (median [IQR]: 10 [7; 13] vs. 12 [8; 15], respectively; p < 0.0001). The ANIi was able to discriminate between over-analgosedation (defined as a CBS score < 10) and normal analgosedation (AUROC = 0.694 during P1).The ANI might be a good candidate for assessing discomfort in intubated, prepubescent patients in the PICU.Trial Registration: NCT04913038.
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