ArticleInfection2026
Severe viral infections requiring intensive care unit admissions- aetiology, co-infections, respiratory interventions and outcomes.
Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Challenges and opportunities in the management of severe pneumonia. Key concepts from the Seventh Annual Meeting of Spanish Experts 2025.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Alveolar dysregulation of host response in pneumonia and ARDS: implications for immune modulation and infection.Annals of intensive care · 2026Review
- Interpretable machine learning identifies immune-inflammatory and immunothrombotic biomarkers for myocardial injury and mortality risk stratification in severe pneumonia with diverse infectious etiologies.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSevere viral infections are common in patients requiring admission to intensive care units (ICU). Furthermore, these patients often have additional secondary or co-infections. Despite their prevalence, it remains uncertain to what extent those additional infections contribute to worse outcomes for patients with severe viral infections requiring ICU admission. This study aims to characterise severe viral infections requiring admission to intensive care, and describe their viral aetiology, the incidence of additional infections, and their clinical outcomes.
methodsThis retrospective single-centre cohort included consecutive adults admitted to the intensive care unit (ICU) with a positive polymerase chain reaction (PCR) test for viral infection from 2015 to 2024. Patients with SARS-CoV-2 were not included in this analysis. The data were retrieved from all available electronic databases. Patients were further stratified to compare severe viral infections alone to those with other microbiology confirmed co-infection (within 48 h of admission) and secondary infection (48 h after ICU admission).
resultsWe identified 222 with positive PCR for viral infection admitted to ICU. The majority were admitted with radiographic evidence of pneumonia (73.0%). Rhinovirus (28.4%), influenza A (18.5%), and RSV (16.2%) were the most common viral pathogens. Of the total, 149 patients had viral infection alone, 50 had co-infections, and 23 developed secondary infections. 30-day and ICU mortality were similar for viral alone, co-infection and secondary infection groups. Although those with secondary infection had a greater hospital and ICU length of stay, this was not reflected in the duration of mechanical ventilation or 30-day hospital mortality.
conclusionIn our large cohort of severe viral infections where Rhinovirus was the most common pathogen. This patient population constitute a high burden of respiratory support. The study also characterised 22.5% had co-infection, and 10% had subsequent secondary infection. While patients with secondary infections had prolonged ICU and hospital stay, the 30-day mortality was similar between all groups.
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