Evidence map›Paper›PMID 40924208›Full record

ArticleJournal of cancer research and clinical oncology2025

DigiNet: Optimizing personalized care for patients with stage IV non-small cell lung cancer (NSCLC) through a digitally connected provider network-analysis plan of a prospective multicenter cohort trial.

Anika Kästner, Anna Kron, Leonie Eilers, Anna Spier, Vanessa Mildenberger, Dusan Simic, Stephanie Stock, Florian Kron, Matthias Scheffler, Gerhard Schillinger and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05818449 (Improvement of Personalized Cancer Care for Patients With Advanced Non-Small Cell Lung Cancer), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05818449 naunknown statusnot on this map

Improvement of Personalized Cancer Care for Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) Through Digital Connection of Specialized Cancer Centers, Community Hospitals, Private Practices and Patients (DigiNet)

TypeinterventionalSponsorUniversity of CologneRan2022 to 2025Enrolled850ConditionsNon-small Cell Lung Cancer Stage IVArmsDigiNet intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anika Kästner *Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Greifswald, Germany.
Anna Kron *National Network Genomic Medicine, University Hospital of Cologne, Cologne, Germany.
Leonie EilersFOM University of Applied Sciences, Essen, Germany.
Anna SpierInstitute of Health Economics and Clinical Epidemiology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.
Vanessa MildenbergerInstitute of Health Economics and Clinical Epidemiology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.
Dusan SimicInstitute of Health Economics and Clinical Epidemiology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.
Stephanie StockInstitute of Health Economics and Clinical Epidemiology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.
Florian KronFOM University of Applied Sciences, Essen, Germany.
Matthias SchefflerNational Network Genomic Medicine, University Hospital of Cologne, Cologne, Germany.
Gerhard SchillingerFederal Association of the AOK, Berlin, Germany.
Neeltje van den BergInstitute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Greifswald, Germany.
Jürgen Wolf *National Network Genomic Medicine, University Hospital of Cologne, Cologne, Germany. juergen.wolf@uk-koeln.de.
Wolfgang Hoffmann *Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Greifswald, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe German sector-based healthcare system poses a major challenge to continuous patient monitoring and long-term follow-up, both essential for generating high-quality, longitudinal real-world data. The national Network for Genomic Medicine (nNGM) bridges the inpatient and outpatient care sectors to provide comprehensive molecular diagnostics and personalized treatment for non-small cell lung cancer (NSCLC) patients in Germany. Building on the established nNGM infrastructure, the DigiNet study aims to evaluate the impact of digitally integrated, personalized care on overall survival (OS) and the optimization of treatment pathways, compared to routine care.

methodsDigiNet is a prospective, controlled, non-randomized multicenter cohort study including patients with stage IV NSCLC in two study regions (East and West) in Germany. The results of molecular diagnostics and clinical information, along with the entire treatment data are documented in a shared database. A board of lung cancer specialists monitors critical events. Patients digitally complete quality of life questionnaires, with results visualized for physicians. To assess the impact of this personalized digital care, a population-based control group will be identified by matching cohorts within the involved cancer registries. The primary endpoint is OS, and secondary endpoints comprise time on first-line treatment and hospitalization rates. Furthermore, a health economic and business economic evaluation will be conducted. Qualitative interviews with patients and physicians will be performed to assess barriers and facilitating factors for implementing the DigiNet intervention. ETHICS: The study protocol was reviewed and approved by the Ethics Committee of the University Hospital of Cologne (21-1521).

trial registrationNCT05818449, registered retrospectively on December 12, 2022.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsPrecision MedicineClinical Trials as TopicGermanyHumansMulticenter Studies as TopicNeoplasm StagingProspective StudiesQuality of LifeCohort studyDigital networkNon-small cell lung cancerPersonalized medicineQuality of lifeReal-world data

Identifiers

PMID40924208
PMCPMC12420542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.