Evidence map›Paper›PMID 40924177›Full record

ArticleAnnals of hematology2025

Age interaction in associations between geriatric nutritional risk index and prognosis in diffuse large B-cell lymphoma.

Kei Fujita, Hikaru Tsukasaki, Shin Lee, Tetsuji Morishita, Eiju Negoro, Kana Oiwa, Takeshi Hara, Hisashi Tsurumi, Takanori Ueda, Takahiro Yamauchi

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kei FujitaDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Hikaru TsukasakiDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Shin LeeDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. leesin.581020@gmail.com.
Tetsuji MorishitaDepartment of Internal Medicine, Matsunami General Hospital, Gifu, Japan.
Eiju NegoroDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Kana OiwaDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Takeshi HaraDepartment of Hematology and Oncology, Matsunami General Hospital, Dendai 185-1 Kasamatsu-cho, Hashima-gun, Gifu, Japan, 501-6062.
Hisashi TsurumiDepartment of Hematology and Oncology, Matsunami General Hospital, Dendai 185-1 Kasamatsu-cho, Hashima-gun, Gifu, Japan, 501-6062.
Takanori UedaDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Takahiro YamauchiDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate whether age modifies the association between the geriatric nutritional risk index (GNRI) and overall survival (OS) in patients aged ≥ 18 years with newly diagnosed diffuse large B-cell lymphoma (DLBCL), we conducted a multi-centre retrospective study of 552 patients. Multivariable Cox regression with restricted cubic spline (RCS) modelling showed that GNRI was significantly associated with OS, but the relationship was non-linear (P for non-linearity = 0.0158). A three-dimensional Cox-RCS model revealed that older age was associated with a higher mortality risk. The association between lower GNRI and worse OS was consistent across all age groups, including younger patients. Among patients with low GNRI (< 92), the most common pattern of malnutrition involved normal albumin (Alb) and body mass index (BMI). This pattern accounted for approximately 40% of low-GNRI patients, regardless of age group (based on thresholds of 65, 70, or 75 years). Survival curves demonstrated that a low GNRI (< 92) predicted poor prognosis, regardless of whether Alb or BMI was the main contributing factor. There was no evidence of interaction between age and GNRI on prognosis. Malnutrition, as measured by GNRI, adversely affects survival in both younger and older DLBCL patients.

Indexed as

Geriatric AssessmentLymphoma, Large B-Cell, DiffuseMalnutritionNutritional StatusNutrition AssessmentAdolescentAdultAgedAged, 80 and overAge FactorsBody Mass IndexFemaleHumansMaleMiddle AgedPrognosisDiffuse large B-cell lymphomaEffect modificationGeriatric nutritional risk indexOlder adultYounger adult

Identifiers

PMID40924177
PMCPMC12672688

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.