Long-term complications in patients with bladder-prostate rhabdomyosarcoma treated with brachytherapy: a systematic review.

Giulia Brooks, Filippo Ghidini, Calogero Virgone, Federica De Corti

Abstract readSystematic Review

In one paragraph

Synthesis in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Giulia BrooksDepartment of Pediatric Surgery and Pediatric Minimally Invasive Surgery and New Technologies, San Bortolo Hospital, Viale Ferdinando Rodolfi 37, 36100, Vicenza, Italy.

Filippo GhidiniDepartment of Women's and Children's Health, University of Padua, Via Nicolò Giustiniani, 35100, Padua, Italy. filippo.ghidini@ch-colmar.fr.

Calogero VirgonePediatric Surgery Unit, Department of Women's and Children's Health, University of Padua, Via Nicolò Giustiniani, 35100, Padua, Italy.

Federica De CortiPediatric Surgery Unit, Department of Women's and Children's Health, University of Padua, Via Nicolò Giustiniani, 35100, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBrachytherapy has been used for the multimodal treatment of pediatric bladder-prostate rhabdomyosarcoma in the last two decades. The aim of this systematic review is to gather the current evidence about this innovative technique with a special focus on long-term outcomes.

methodsAccording to PRISMA criteria, PubMed, Scopus, and Web of Science were searched for papers published between 2000 and 2022.

resultsThe search yielded 7338 papers but only seven were eligible, for a total of 196 children with a median age ranging from 23 to 32 months and a median follow-up ranging from eight to 64 months. The five-year overall survival was superior to 90%. However, at least one complication involving the urogenital apparatus was reported in 66 children (35%).

conclusionBrachytherapy presented positive outcomes in terms of overall survival. On the other hand, further efforts should be made to decrease the risk of functional urogenital side effects.

Indexed as

BrachytherapyProstatic NeoplasmsRhabdomyosarcomaUrinary Bladder NeoplasmsChildChild, PreschoolHumansInfantMaleBrachytherapyChildrenLong-term outcomesRhabdomyosarcoma

Identifiers

PMID40924160

DOI10.1007/s00383-025-06112-9

PMCPMC12420684

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