Evidence map›Paper›PMID 40924093›Full record

ArticleArchives of gynecology and obstetrics2025

Non-invasive left ventricular myocardial work indices in preterm neonates born to mothers with severe preeclampsia in pregnancy.

Huiyun Chen, Xiaoyu Li, Fangcan Sun, Jingjing Zhang, Weizeyu Liu, Xinran Dong, Hong Li, Qiuqin Xu, Bing Han

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In one paragraph

Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Huiyun ChenThe First Affiliated Hospital of Soochow University, No. 899 Pinghai Street, Suzhou, Jiangsu, China.
Xiaoyu LiThe First Affiliated Hospital of Soochow University, No. 899 Pinghai Street, Suzhou, Jiangsu, China.
Fangcan SunThe First Affiliated Hospital of Soochow University, No. 899 Pinghai Street, Suzhou, Jiangsu, China.
Jingjing ZhangThe First Affiliated Hospital of Soochow University, No. 899 Pinghai Street, Suzhou, Jiangsu, China.
Weizeyu LiuThe First Affiliated Hospital of Soochow University, No. 899 Pinghai Street, Suzhou, Jiangsu, China.
Xinran DongThe First Affiliated Hospital of Soochow University, No. 899 Pinghai Street, Suzhou, Jiangsu, China.
Hong LiChildren's Hospital of Soochow University, No.92 Zhongnan Street, Suzhou, Jiangsu, China.
Qiuqin XuChildren's Hospital of Soochow University, No.92 Zhongnan Street, Suzhou, Jiangsu, China.
Bing HanThe First Affiliated Hospital of Soochow University, No. 899 Pinghai Street, Suzhou, Jiangsu, China. hanbing@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study utilized non-invasive myocardial work indices to investigate myocardial injury in infants born to mothers with severe preeclampsia (SPE) and to explore the duration of this myocardial damage during the neonatal period.

methodsThis prospective study included 34 preterm infants born to mothers with SPE and 28 preterm infants born to mothers without severe pregnancy complications (termed "controls"). Echocardiography was performed in infants within 24 h of birth, then again at 48-72 h and 14-28 days, to obtain echocardiographic parameters. Two-dimensional speckle-tracking echocardiography (2D STE) was performed to construct a non-invasive left ventricular pressure-strain loop based on two-dimensional myocardial strain and non-invasive left ventricular systolic pressure measurements, allowing for the calculation of myocardial work indices.

resultsWithin 24 h after delivery, left ventricular stroke volume (SV), cardiac output (CO), and left ventricular global work index (GWI) in newborns born of mothers with SPE were significantly reduced compared to controls, while mitral E/e' and left ventricular longitudinal strain were increased. At 48-72 h after birth, mitral E/e' and left ventricular global waste work (GWW) increased, and global work efficiency (GWE) was reduced in infants of mothers with SPE. During the 14-28 days of the neonatal period, left ventricular SV and CO were reduced in the offspring of mothers with SPE and mitral E peak velocity, and E/e' and left ventricular GWW were increased.

conclusionThe adverse intrauterine environment caused by SPE can lead to persistent impaired left ventricular function in preterm infants during the neonatal period.

Indexed as

Infant, PrematurePre-EclampsiaVentricular Function, LeftAdultCardiac OutputCase-Control StudiesEchocardiographyFemaleHeart VentriclesHumansInfant, NewbornMalePregnancyProspective StudiesStroke VolumeEchocardiographyMyocardial workPreeclampsiaPremature birth

Identifiers

PMID40924093
PMCPMC12589262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.