Evidence map›Paper›PMID 40924061›Full record

ArticleMicrobiology spectrum2025

Diagnostic and prognostic roles of interferon-λ1 and interferon-λ3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with invasive pulmonary aspergillosis.

Chao Sun, Huanhuan Zhong, Yajie Lu, Yuchen Cai, Yuanyuan Li, Yujie Wang, Tingting Zhao, Li Wang, Chunlai Feng, Wenkui Sun and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chao SunDepartment of Respiratory and Critical Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID 0009-0005-3842-9296
Huanhuan ZhongDepartment of Respiratory and Critical Medicine, the Second Affiliated Hospital of Soochow University, Suzhou, China.
Yajie LuDepartment of Respiratory and Critical Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yuchen CaiDepartment of Respiratory and Critical Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yuanyuan LiDepartment of Respiratory and Critical Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yujie WangDepartment of Respiratory and Critical Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Tingting ZhaoDepartment of Respiratory and Critical Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Li WangDepartment of Respiratory and Critical Medicine, Nanjing First Hospital, Nanjing, China.
Chunlai FengDepartment of Respiratory and Critical Medicine, Changzhou First People's Hospital, Changzhou, China.
Wenkui SunDepartment of Respiratory and Critical Medicine, Jiangsu Province Hospital, Nanjing, China.ORCID 0000-0002-2992-9783
Cheng ChenDepartment of Respiratory and Critical Medicine, the First Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0000-0002-9583-7991
Yujian TaoDepartment of Respiratory and Critical Medicine, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Guoer MaDepartment of Respiratory and Critical Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Binchan HeDepartment of Respiratory and Critical Medicine, Jiangsu Province Second Chinese Medicine Hospital, Nanjing, China.
Xinyu WangDepartment of Respiratory and Critical Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jinjin ZhongDepartment of Respiratory and Critical Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xin LuDepartment of Respiratory and Critical Medicine, Nanjing Jiangning Hospital, Nanjing, China.
Yuanqin LiDepartment of Respiratory and Critical Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Xin SuDepartment of Respiratory and Critical Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID 0000-0002-3910-9156

Funding

Nanjing Drum Tower Hospital 2023-LCYJ-MS-18National Natural Science Foundation of China 82570016, 82270019National Science and Technology Major Project 2024ZD0522500
6 · The paper itself

Abstract

This study aims to evaluate the diagnostic and prognostic value of interferon (IFN)-λ1 and IFN-λ3 levels in bronchoalveolar lavage fluid (BALF) and plasma in non-neutropenic invasive pulmonary aspergillosis (IPA) patients. A total of 481 patients suspected of IPA were enrolled (169 IPA cases and 312 non-IPA cases) in this study. BALF and plasma samples were collected, and IFN-λ1 and IFN-λ3 levels were measured using an enzyme-linked immunosorbent assay. In IPA patients, BALF IFN-λ1 and IFN-λ3 levels were significantly higher than in non-IPA patients (IFN-λ1: 284.60 [229.12, 357.99] pg/mL vs. 189.50 [140.00, 233.69] pg/mL,

Indexed as

Bronchoalveolar Lavage FluidInterferonsInterleukinsInvasive Pulmonary AspergillosisPlasmaAdultAgedFemaleHumansInterferon LambdaMaleMiddle AgedPrognosisInterferon Lambdainterferon-lambda, humanInterferonsInterleukinsdiagnosisinterferon-λ1interferon-λ3invasive pulmonary aspergillosisprognosis

Identifiers

PMID40924061
PMCPMC12502686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.