ArticleACS applied materials & interfaces2025
Proto-SLIPS: Slippery Liquid-Infused Surfaces that Release Highly Water-Soluble Agents.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Slippery liquid-infused porous surfaces (or "SLIPS") can prevent bacterial surface fouling, but they do not inherently possess the means to kill bacteria or reduce cell loads in surrounding media. Past reports show that the infused liquids in these materials can be leveraged to load and release antimicrobial agents, but these approaches are generally limited to the use of hydrophobic agents that are soluble in the infused oily phases. Here, we report the design of so-called "proto-SLIPS" that address this limitation and permit the release of highly water-soluble (or oil-insoluble) agents. This approach involves the physical patterning of small, dried spots of hydrophilic drugs on the surfaces of hydrophobic porous materials and leads to analogs of conventional SLIPS that contain drug-patterned regions that can dissolve and disperse on exposure to water. We show that proto-SLIPS fabricated by patterning the antibiotic gentamicin on model porous PTFE membranes release drug rapidly, followed by a rapid process of self-healing in which oil from surrounding areas is transported to regions vacated by the drug. This healing process leads to uniform oil-infused surfaces with inherent antibiofouling properties similar to those of conventional SLIPS. The results of microbiological studies demonstrate that gentamicin-patterned proto-SLIPS can kill the common human bacterial pathogen
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