Evidence map›Paper›PMID 40923940›Full record

ArticleEpilepsia2025

Development and characterization of an autoresuscitation test for preclinical SUDEP models.

Shruthi H Iyer, Jillian E Hinman, Samantha B Draves, Stephanie A Matthews, Kristina A Simeone, Timothy A Simeone

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shruthi H IyerDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0002-7164-2495
Jillian E HinmanDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
Samantha B DravesDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
Stephanie A MatthewsDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
Kristina A SimeoneDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0001-5072-3694
Timothy A SimeoneDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0002-8716-7211

Funding

Autoresuscitation and SUDEPR01NS126418 · NINDS · CREIGHTON UNIVERSITY · PI Kristina A Simeone, Timothy A. Simeone · 2022 to 2026
$1.7M
Replacing an Animal Resource Facility Cage Washer.G20RR024001 · NCRR · CREIGHTON UNIVERSITY · PI DRESCHER, KRISTEN · 2007 to 2007
$638k
Mechanisms of SUDEP: Failure to AutoresuscitateR21NS111389 · NINDS · CREIGHTON UNIVERSITY · PI SIMEONE, KRISTINA A · 2020 to 2020
$400k
NCRR NIH HHS G20 RR024001NIH HHS G20RR024001NIH HHS National Institutes of Health NINDSR21NS111389(KAS)NIH HHS R01NS126418 (TAS/KAS)NINDS NIH HHS R01 NS126418NINDS NIH HHS R21 NS111389State of Nebraska LB692 Tobacco Settlement Biomedical Research Development Fund Award(TAS)
6 · The paper itself

Abstract

The rate of sudden unexpected death in epilepsy (SUDEP) is ~1 per 1000 patients each year. Terminal events reportedly involve repeated and prolonged apnea, suggesting a failure to autoresuscitate. To better understand the mechanisms and identify novel therapeutics, standardized tests to screen for autoresuscitation efficacy are needed in preclinical SUDEP. To investigate the efficacy of the autoresuscitation response and potential contribution to SUDEP susceptibility, we adapted an anoxia-induced autoresuscitation test. The test was optimized to allow for survival of most wild-type (WT) mice, whereas autoresuscitation failure occurred for most Kcna1

Indexed as

Disease Models, AnimalSudden Unexpected Death in EpilepsyAnimalsApneaHypoxiaKv1.1 Potassium ChannelMaleMiceMice, Inbred C57BLMice, KnockoutPlethysmography, Whole BodyKcna1 protein, mouseKv1.1 Potassium ChannelanoxiaautoresuscitationchemosensingKcna1‐null micerespirationsudden unexpected death in epilepsy

Identifiers

PMID40923940
PMCPMC12818031

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.