Evidence map›Paper›PMID 40923903›Full record

ArticleUnited European gastroenterology journal2025

Plasmapheresis in Acute Hypertriglyceridemia-Induced Pancreatitis-The PHIP-JuGa-Study.

Jonas J Staudacher, Elisabeth Blüthner, Katharina Murillo, Manja Boldt, Karim Hamesch, Leah Kruse, Sabrina Sulzer, Christoph Ammer-Herrmenau, Yvonne Huber, Julia Weinmann-Menke and 15 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jonas J StaudacherDepartment of Gastroenterology, Rheumatology and Infectiology, Charité-University Medicine Berlin-Campus Benjamin Franklin, Berlin, Germany.ORCID https://orcid.org/0000-0001-5697-2798
Elisabeth BlüthnerBerlin Institute of Health at Charité, Berlin, Germany.ORCID https://orcid.org/0000-0002-7008-8795
Katharina MurilloDepartment of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany.
Manja BoldtDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.
Karim HameschMedical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.ORCID https://orcid.org/0000-0002-1702-2746
Leah KruseMedical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
Sabrina SulzerDepartment of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.
Christoph Ammer-HerrmenauDepartment of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.ORCID https://orcid.org/0009-0009-2465-8927
Yvonne HuberDepartment of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Julia Weinmann-MenkeDepartment of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Charlotte KramerDepartment of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Jakob GarbeDepartment of Internal Medicine I, University Hospital Halle (Saale), Halle (Saale), Germany.ORCID https://orcid.org/0000-0001-8043-763X
Rene WilkeDepartment of Internal Medicine I, University Hospital Halle (Saale), Halle (Saale), Germany.ORCID https://orcid.org/0000-0001-8980-6884
Marcus M MückeMedical Clinic I, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Myriam W HeilaniMedical Clinic I, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Elisabeth Orgler-GascheDepartment of Medicine II, LMU University Hospital, Munich, Germany.
Marlies VornhülzDepartment of Medicine II, LMU University Hospital, Munich, Germany.ORCID https://orcid.org/0000-0003-1197-0419
Georg BeyerDepartment of Medicine II, LMU University Hospital, Munich, Germany.ORCID https://orcid.org/0000-0002-7607-8264
Lara WiesehahnDepartment for Gastroenterology, Hepatology, Diabetology and Nutritional Medicine, Diakonieklinikum Rotenburg Wümme, Rotenburg, Germany.
Annekatrin SchwanstecherDepartment for Gastroenterology, Hepatology, Diabetology and Nutritional Medicine, Diakonieklinikum Rotenburg Wümme, Rotenburg, Germany.
Marcus HollenbachDepartment of Gastroenterology, Endocrinology, Infectious Diseases, Marburg University, Marburg, Germany.
Hendrik LuxenburgerDepartment of Medicine II, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.
Dominik BettingerDepartment of Medicine II, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-8782-8729
Sophie Schlosser-HupfDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.
JuGa study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe incidence of acute pancreatitis is increasing in the Western world. About 10% of cases are caused by hypertriglyceridemia. Plasmapheresis was shown to reduce serum triglyceride (TG) levels, and current apheresis guidelines recommend its use in severe acute hypertriglyceridemia-induced pancreatitis (HIP). However, data on safety and efficacy are lacking. This study aimed to evaluate the clinical efficacy of plasmapheresis in hypertriglyceridemia-induced pancreatitis.

methodsThis is a retrospective multicenter cohort study of patients hospitalized for an episode of hypertriglyceridemia-induced pancreatitis from January 1, 2012 to December 31, 2022. The predefined composite primary endpoint was in-hospital mortality and organ failure. To reduce allocation bias, we performed propensity score matching.

results245 episodes of hypertriglyceridemia-induced pancreatitis from 13 German centers were included. Of those, 95 episodes were treated with plasmapheresis. After propensity score matching, the final cohort consisted of 60 well-balanced pairs. Plasmapheresis was not associated with a difference in the primary composite outcome, in-hospital mortality, and organ failure (8/60 vs. 5/60; χ

conclusionsPlasmapheresis in patients with hypertriglyceridemia-induced pancreatitis was not associated with a better clinical outcome compared with conservative treatment in this propensity score-matched retrospective cohort study. Outside clinical studies, this costly and potentially complicative treatment should be considered with caution.

Indexed as

HypertriglyceridemiaPancreatitisPlasmapheresisAcute DiseaseAdultAgedFemaleGermanyHospital MortalityHumansMaleMiddle AgedPropensity ScoreRetrospective StudiesSeverity of Illness IndexTreatment OutcomeTriglyceridesacute pancreatitishypertriglyceridemiahypertriglyceridemia‐induced pancreatitismortalityorgan failureplasmapheresispropensity‐score‐matchingserum triglyceride

Identifiers

PMID40923903
PMCPMC12704568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.