Evidence map›Paper›PMID 40923709›Full record

ArticleThe Kaohsiung journal of medical sciences2026

The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical-Induced Murine MASH Model.

Szu-Jen Wang, Yung-Ho Wang, Jee-Fu Huang, En-Sheng Lin, Wei-Shiun Chen, Chia-Yang Li, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu, Shu-Chi Wang

Abstract read
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Frontiers in pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Szu-Jen WangGraduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yung-Ho WangSchool of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jee-Fu HuangHepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-2752-7051
En-Sheng LinHepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity; Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wei-Shiun ChenHepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity; Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chia-Yang LiGraduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chia-Yen DaiHepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-2296-3054
Wan-Long ChuangHepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-2376-421X
Ming-Lung YuHepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-8145-1900
Shu-Chi WangHepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity; Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-9691-7507

Funding

Center for Metabolic Disorders and Obesity, Kaohsiung Medical UniversityKaohsiung Medical UniversityKaohsiung Medical University HospitalMinistry of Education (MOE)Yuan's General Hospital
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly prevalent chronic liver condition that can progress to severe complications such as metabolic dysfunction-associated steatohepatitis (MASH). Despite its growing burden, there are no reliable non-invasive biomarkers for tracking disease progression. In this study, we established a murine MASLD/MASH model using a high-fat diet and chemical (CCl

Indexed as

Diet, WesternExtracellular VesiclesFatty LiverProteomicsAnimalsBiomarkersCathepsin BDiet, High-FatDisease Models, AnimalMaleMiceMice, Inbred C57BLProteomeReceptors, Polymeric ImmunoglobulinSaposinsBiomarkersCathepsin BProteomeReceptors, Polymeric ImmunoglobulinSaposinsbiomarkerextracellular vesicles (EVs)metabolic‐associated steatohepatitis (MASH)metabolic‐associated steatotic liver disease (MASLD)proteomic

Identifiers

PMID40923709
PMCPMC12884771

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.