Evidence map›Paper›PMID 40923569›Full record

ArticleAnnals of clinical and translational neurology2025

Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72.

Diederik J L Stikvoort García, H Stephan Goedee, Leonard H van den Berg, Boudewijn T H M Sleutjes

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In one paragraph

Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Diederik J L Stikvoort GarcíaDepartment of Neurology, Brain Centre Utrecht, University Medical Centre Utrecht, Utrecht, the Netherlands.ORCID 0000-0003-3984-1635
H Stephan GoedeeDepartment of Neurology, Brain Centre Utrecht, University Medical Centre Utrecht, Utrecht, the Netherlands.
Leonard H van den BergDepartment of Neurology, Brain Centre Utrecht, University Medical Centre Utrecht, Utrecht, the Netherlands.
Boudewijn T H M SleutjesDepartment of Neurology, Brain Centre Utrecht, University Medical Centre Utrecht, Utrecht, the Netherlands.ORCID 0000-0001-6618-3573

Funding

Stichting ALS Nederland
6 · The paper itself

Abstract

objectiveWe investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients.

methodsWe included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9

resultsIn the subset of asymptomatic individuals from the same families, C9

interpretationAsymptomatic individuals and ALS patients carrying the C9orf72 mutation exhibit a unique electrophysiological phenotype, implicating altered Na

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinMedian NerveAdultAgedFemaleHeterozygoteHumansMaleMiddle AgedMutationC9orf72 ProteinC9orf72 protein, humanamyotrophic lateral sclerosisC9orf72nerve excitability

Identifiers

PMID40923569
PMCPMC12698937

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.