Evidence map›Paper›PMID 40923525›Full record

ArticleGut microbes2025

Parity influences on the infant gut microbiome development: a longitudinal cohort study.

R Prasad, A Angelova, P Subramanian, S Namasivayam, Q Chen, K Banks, S Levy, G L Maxwell, S K Hourigan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

R PrasadClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
A AngelovaBioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
P SubramanianBioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
S NamasivayamClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
Q ChenClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
K BanksClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
S LevyClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
G L MaxwellWomen's Service Line, Inova Health System, Falls Church, VA, USA.
S K HouriganClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.

Funding

The contribution of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity.K23HD099240 · NICHD · INOVA HEALTH CARE SERVICES · PI HOURIGAN, SUCHITRA · 2019 to 2021
$476k
NICHD NIH HHS K23 HD099240NIH HHS 75N93022F00001NIH HHS HHSN316201300006W
6 · The paper itself

Abstract

Parity, the number of pregnancies carried beyond 20 weeks, influences the maternal gut microbiome. However, whether parity modulates the infant microbiome longitudinally remains underexplored. To address this, 746 infants in a longitudinal cohort study were assessed. Serial infant stool samples collected at 2, 6, 12, and 24 months underwent 16S ribosomal RNA gene sequencing. Mothers were stratified by parity: 1 = 32.6%, 2 = 42.0%, 3 = 18.6%, 4, 5, 6 or 7 = 6.8%. Although no differences in alpha diversity were found with parity, significant differences were found in microbiome composition (beta diversity, Bray-Curtis) by parity at each time point through the first year of life (

Indexed as

BacteriaGastrointestinal MicrobiomeParityAdultCesarean SectionCohort StudiesDelivery, ObstetricFecesFemaleHumansInfantInfant, NewbornLongitudinal StudiesMalePregnancyRNA, Ribosomal, 16SRNA, Ribosomal, 16Sdelivery modeMicrobiotaneonateperipartum antibioticspregnancy

Identifiers

PMID40923525
PMCPMC12427479

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.