Evidence map›Paper›PMID 40923468›Full record

ArticleAngewandte Chemie (International ed. in English)2025

MitoSiege-Driven Catalase Collapse: A GSH-Responsive, Mitochondria-Targeted COF Prodrug for Amplified Chemodynamic Therapy.

Qihang Ding, Bo Wang, Zixuan Zhan, Paramesh Jangili, Junyang Chen, Rakesh Mengji, Hyeonji Rha, Yang Li, Jian Tian, Jong Seung Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qihang Ding *Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.ORCID 0000-0002-2665-9036
Bo Wang *Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
Zixuan Zhan *Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Paramesh Jangili *Department of Chemistry, Korea University, Seoul, 02841, South Korea.
Junyang ChenDepartment of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
Rakesh MengjiDepartment of Chemistry, Korea University, Seoul, 02841, South Korea.
Hyeonji RhaDepartment of Chemistry, Korea University, Seoul, 02841, South Korea.
Yang LiSchool of Chemical Engineering & Pharmacy, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan, 430079, China.
Jian TianDepartment of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
Jong Seung KimDepartment of Chemistry, Korea University, Seoul, 02841, South Korea.ORCID 0000-0003-3477-1172

Funding

China Scholarship Council 202106270027National Natural Science Foundation of China NSFC22271222National Natural Science Foundation of China NSFC22307036National Research Foundation of Korea 2018R1A3B1052702
6 · The paper itself

Abstract

Chemodynamic therapy (CDT), leveraging Fenton reactions to generate hydroxyl radicals (•OH) from intracellular hydrogen peroxide (H

Indexed as

Antineoplastic AgentsCatalaseGlutathioneMetal-Organic FrameworksMitochondriaProdrugsAnimalsHumansHydrogen PeroxideMiceAntineoplastic AgentsCatalaseGlutathioneHydrogen PeroxideMetal-Organic FrameworksProdrugsChemodynamic therapyCovalent organic frameworkFenton‐like reactionMitochondriaTumor microenvironment

Identifiers

PMID40923468
PMCPMC12559460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.