Evidence map›Paper›PMID 40923451›Full record

ReviewAngewandte Chemie (International ed. in English)2025

Considerations in Pursuing Reaction Scope Generality.

Samson B Zacate, Juliana A Dantas, Song Lin, Abigail G Doyle, Matthew S Sigman

Abstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Considerations in Pursuing Reaction Scope Generality.Angewandte Chemie (International ed. in English) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samson B Zacate *Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Juliana A Dantas *Department of Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.
Song LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.ORCID https://orcid.org/0000-0002-8880-6476
Abigail G DoyleDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Matthew S SigmanDepartment of Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.

Funding

Data Science Guided Organic Reaction DevelopmentR35GM136271 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MATTHEW S SIGMAN · 2020 to 2026
$3.5M
Electrochemistry as an enabling tool for reaction discoveryR01GM130928 · NIGMS · STANFORD UNIVERSITY · PI Song Lin · 2018 to 2026
$3.4M
Radical redox catalysis by Ti complexesR01GM134088 · NIGMS · STANFORD UNIVERSITY · PI Song Lin · 2020 to 2026
$2.4M
National Science Foundation Graduate Research DGE-2139899NIGMS NIH HHS R01 GM130928NIGMS NIH HHS R01 GM134088NIGMS NIH HHS R35 GM136271NIH HHS R01 GM130928NIH R35 GM136271NSF CCAS CHE-2202693
6 · The paper itself

Abstract

The term "generality" has recently been popularized in synthetic chemistry, owing largely to the increasing use of high-throughput technology for producing vast quantities of data and the emergence of data science tools to plan and interpret these experiments. Despite this, the term has not been clearly defined, and there is no standardized approach toward developing a method with a diverse (general) scope. This minireview will examine different emerging strategies toward achieving generality using selected examples and aims to give the reader an overview of modern workflows that have been used to expedite this pursuit.

Indexed as

Computational chemistryGeneralityHigh‐throughput screeningMachine learningSynthetic methods

Identifiers

PMID40923451
PMCPMC12501685

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.