ArticleAnnals of African medicine2026
Study of Thyroid Function Tests and Inflammatory Markers (White Blood Cell Count and High-sensitivity C-reactive Protein) in Prediabetic Patients at Tertiary Care Center.
Article in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrediabetes represents a transitional state in glucose metabolism with an increasing global and national prevalence, particularly in India. Recent evidence suggests that both thyroid dysfunction and chronic low-grade inflammation may play pivotal roles in the progression of prediabetes to overt Type 2 diabetes mellitus (T2DM). Thyroid hormones regulate glucose metabolism, while inflammatory markers such as white blood cell (WBC) count and high-sensitivity C-reactive protein (hs-CRP) are indicators of systemic inflammation often elevated in metabolic disorders.
objectivesThis study aimed to evaluate thyroid function and inflammatory markers in prediabetic individuals, assess the prevalence of thyroid dysfunction, and analyze the correlation between thyroid parameters and inflammatory markers. MATERIALS AND
methodsA case-control study was conducted at a tertiary care center in Western Maharashtra, enrolling 200 participants (130 prediabetics and 70 age- and sex-matched controls). Thyroid function tests (thyroid-stimulating hormone [TSH], Total T3 and T4), thyroid antibodies, WBC count, and hs-CRP levels were analyzed and compared between groups. Statistical analyses were conducted to evaluate correlations and significance.
resultsThyroid dysfunction, particularly elevated TSH levels, was more prevalent in prediabetic individuals compared to controls. A significant proportion of prediabetic patients exhibited elevated hs-CRP and WBC counts, indicating underlying low-grade inflammation. A positive correlation was observed between TSH levels and inflammatory markers, suggesting a possible link between early thyroid dysfunction and systemic inflammation in prediabetic states.
conclusionPrediabetes is associated with both subclinical thyroid abnormalities and elevated inflammatory markers, highlighting the need for comprehensive metabolic screening in this population. Early identification and management of thyroid and inflammatory dysfunction may offer an opportunity to delay or prevent the onset of T2DM and its complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.