Evidence map›Paper›PMID 40923219›Full record

ArticleOrthodontics & craniofacial research2025

Metabolites From Salivary Exosomes as Potential Biomarkers for Alveolar Bone and Tooth Resorption.

W J Rody, L M Shaddox, K Olli, A Martinez-Porras, T J Garrett, J G Cagmat, L S Holliday

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Article in Orthodontics & craniofacial research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

W J RodyDepartment of Orthodontics and Dentofacial Orthopedics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-5496-7642
L M ShaddoxDepartment of Oral Health Practice, Periodontology Division, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0003-0948-1667
K OlliSchool of Dental Medicine, Stony Brook University, Stony Brook, New York, USA.
A Martinez-PorrasDepartment of Restorative Dentistry and Prosthodontics, The University of Texas Health Science Center at Houston, School of Dentistry, Houston, Texas, USA.
T J GarrettDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA.
J G CagmatSoutheast Center for Integrated Metabolomics, University of Florida, Gainesville, Florida, USA.
L S HollidayDepartment of Orthodontics, College of Dentistry, University of Florida, Gainesville, Florida, USA.

Funding

Development of an exosome-based diagnostic platform for periodontal disease and root resorptionR03DE027504 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI RODY, WELLINGTON J · 2018 to 2019
$319k
NIDCR NIH HHS R03 DE027504NIH HHS R03DE027504
6 · The paper itself

Abstract

OBJECTIVE(S): In this pilot study, exosomes from saliva were isolated and tested for the presence of metabolomic biomarkers for physiological external root resorption and/or pathological alveolar bone resorption. SETTINGS AND SAMPLE POPULATION: Saliva samples of 20 individuals in the mixed dentition stage of dental development. MATERIALS AND

methodsSaliva was obtained from healthy control children with resorbing primary teeth or children with localised aggressive periodontitis (LAP) showing alveolar bone loss but little root resorption. Exosomes were isolated by differential centrifugation and analysed by electron microscopy, nanoparticle tracking analysis (NTA) and enzyme-linked immunosorbent assay (ELISA). Subsequently, exosomes were subjected to mass spectrometry to identify and quantitate metabolites. Differences between groups were statistically determined.

resultsOver 2000 metabolites were detected in salivary exosomes. Metabolites that differed significantly between exosomes from the saliva of LAP patients and controls included L-pipecolic acid, acetylcholine, creatinine, N-acetylneuraminate and numerous unidentified molecules.

conclusionThis pilot study provided a proof-in-principle for using metabolites from salivary exosomes as biomarkers.

Indexed as

Alveolar Bone LossExosomesRoot ResorptionSalivaTooth ResorptionAggressive PeriodontitisBiomarkersCase-Control StudiesChildEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMass SpectrometryPilot ProjectsTooth, DeciduousBiomarkersexosomesextracellular vesicleslocalised aggressive periodontitismetabolomicsroot resorptionsaliva

Identifiers

PMID40923219
PMCPMC12704453

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.