Evidence map›Paper›PMID 40923200›Full record

Trial reportPain management2025

Impact of preoperative quadratus lumborum block on postoperative opioid consumption after laparoscopic hysterectomy: a double-blind randomized controlled trial.

Kathryn Edmonds, Kiley Hunkler, Christopher Creedon, Sara Drayer, Scott Endicott, Kathryn Eliasen, Candice Jones-Cox

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06709716 (Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06709716 phase4not yet recruitingnot on this map

Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy: a Double-blinded Randomized Controlled Trial

TypeinterventionalSponsorWalter Reed National Military Medical CenterRan2024 to 2026Enrolled76ConditionsPostoperative Pain, Laparoscopic Hysterectomy, Nerve Block, Quadratus Lumborum BlockArmsQuadratus Lumborum Block (QLB), Quadratus lumborum block, Local Anesthetic Solution
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathryn EdmondsMinimally Invasive Gynecologic Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA.ORCID 0000-0002-5795-7757
Kiley HunklerReproductive Endocrinology & Infertility, Walter Reed National Military Medical Center, Bethesda, MD, USA.ORCID 0009-0002-6292-712X
Christopher CreedonRegional Anesthesia, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Sara DrayerGynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD, USA.ORCID 0000-0001-7224-2162
Scott EndicottMinimally Invasive Gynecologic Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA.ORCID 0000-0002-7971-1926
Kathryn EliasenRegional Anesthesia, Walter Reed National Military Medical Center, Bethesda, MD, USA.ORCID 0000-0001-8949-3849
Candice Jones-CoxMinimally Invasive Gynecologic Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA.ORCID 0000-0003-3497-7867

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGynecologic enhanced recovery after surgery (ERAS) pathways have been developed to reduce postoperative narcotic use through multimodal pain management. While incisional injection of local anesthetic is standard practice, regional nerve blockades using liposomal agents are emerging as a promising adjunct technique for post-laparoscopy pain. Current data are conflicting regarding the benefits of regional nerve blocks on postoperative pain after laparoscopic hysterectomy.

objectivesTo determine the impact of preoperative quadratus lumborum (QL) block on postoperative pain following laparoscopic hysterectomy. Our primary outcomes will be intraoperative and immediate postoperative opioid use (within 24 hours). Secondary outcomes will include pain scores, functional impact of pain, and postoperative complications. STUDY

designThis is a prospective, double-blind, randomized-controlled trial comparing opioid use in women undergoing laparoscopic hysterectomy who receive a preoperative QL block to local injection. Seventy-six patients undergoing laparoscopic or robotic hysterectomy will be randomized to the study arm, preoperative QL block with liposomal bupivacaine and intraoperative placebo incisional injection of 0.9% saline, or the control arm, preoperative sham QL block with 0.9% saline and intraoperative incisional injection of 0.25% bupivacaine. Outcomes will be measured at several timepoints: intraoperative, postoperative prior to discharge, and 1, 3, 5, 14 days, and 4-6 weeks postoperatively. CLINICAL

trial registrationwww.clinicaltrials.gov identifier is NCT06709716.

Indexed as

Analgesics, OpioidHysterectomyLaparoscopyNerve BlockPostoperative PainAdultAnesthetics, LocalBupivacaineDouble-Blind MethodFemaleHumansMiddle AgedPreoperative CareProspective StudiesAnalgesics, OpioidAnesthetics, LocalBupivacaineERAS (enhanced recovery after surgery)Laparoscopic hysterectomyopioid usepostoperative pain controlquadratus lumborum (QL) blockregional nerve block

Identifiers

PMID40923200
PMCPMC12584603

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