ArticleInternational journal of laboratory hematology2026
Diagnostic Performance of Prothrombin Time and Activated Partial Thromboplastin Time in Children: A Service Evaluation.
Article in International journal of laboratory hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Diagnostic Performance of Prothrombin Time and Activated Partial Thromboplastin Time in Children: A Service Evaluation.International journal of laboratory hematology · 2026Article
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5 authors.
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Abstract
backgroundCoagulation screening, consisting of prothrombin time (PT) and activated partial prothrombin time (aPTT), is routinely performed in paediatrics to identify bleeding disorders or guide peri-procedural management. We evaluated the trends in utilisation and diagnostic yield of PT and aPTT testing as part of coagulation screening in a tertiary paediatric centre.
methodsAll PT and aPTT samples received from June to September 2024 were analysed. Total requests, sample rejection rates, abnormal result patterns (isolated PT, isolated APTT, combined), and clinical correlations were recorded. Laboratory cutoffs were PT > 12.5 s and APTT > 30.0 s. Youden's Index determined cutoffs associated with inherited bleeding disorders.
resultsA total of 2808 coagulation profiles from 1207 patients were received, with 15.7% (442/2808) rejected in 268 patients. Of these, 31.7% (85/268) of patients were not re-tested. Among valid requests, 17.0% (402/2366) were abnormal (128 isolated APTT, 173 isolated PT, 101 combined). In a subgroup of 337 randomly selected patients, 28.8% (97/337) had deranged results, leading to 12 new haematological and 34 acute diagnoses. Youden's index determined isolated APTT > 31.4 s associated with inherited disorders (AUC > 0.8). The same was not identified with isolated PT (PT > 13.0 s, AUC < 0.6).
conclusionA substantial proportion of samples received are rejected, and some abnormal results remain unaddressed. Most abnormal findings are clinically significant, particularly when APTT > 33.1 s. There is scope to refine utilisation in paediatric practice.
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