Evidence map›Paper›PMID 40923121›Full record

ArticleBrain and behavior2025

Construction of Predictive Machine Learning Model of Glioma-Associated Gut Microbiota.

Ze Li, Kai Zhao, Hongyu Liu, Jialin Liu, Xu Chen, Wentao Hu, Er Wen, Kai Zhang, Ling Chen

Abstract read
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ze LiDepartment of Neurosurgery, First Medical Center of the Chinese PLA General Hospital, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0001-6918-9620
Kai ZhaoDepartment of Neurosurgery, First Medical Center of the Chinese PLA General Hospital, Beijing, People's Republic of China.
Hongyu LiuDepartment of Neurosurgery, First Medical Center of the Chinese PLA General Hospital, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0002-1571-0385
Jialin LiuDepartment of Neurosurgery, First Medical Center of the Chinese PLA General Hospital, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0001-6625-3076
Xu ChenChina Medical University, Shenyang, People's Republic of China.
Wentao HuDepartment of Neurosurgery, First Medical Center of the Chinese PLA General Hospital, Beijing, People's Republic of China.
Er WenDepartment of Neurosurgery, First Medical Center of the Chinese PLA General Hospital, Beijing, People's Republic of China.
Kai ZhangDepartment of Neurosurgery, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, People's Republic of China.
Ling ChenDepartment of Neurosurgery, First Medical Center of the Chinese PLA General Hospital, Beijing, People's Republic of China.

Funding

the National Natural Science Foundation of China 82172680the National Natural Science Foundation of China 82303586the National Natural Science Foundation of China 82373220the National Natural Science Foundation of China 82473264the Research on Neurological Diseases and Nutritional Health at the Capacity Building and Continuing Education Center of the National Health Commission of China W2024SNKT13
6 · The paper itself

Abstract

backgroundThe gut microbiota plays a crucial role in the development of glioma. With the evolution of artificial intelligence technology, applying AI to analyze the vast amount of data from the gut microbiome indicates the potential that artificial intelligence and computational biology hold in transforming medical diagnostics and personalized medicine.

methodsWe conducted metagenomic sequencing on stool samples from 42 patients diagnosed with glioma after operation and 30 non-intracranial tumor patients and developed a Gradient Boosting Machine (GBM) machine learning model to predict the glioma patients based on the gut microbiome data.

resultsThe AUC-ROC for the GBM model was 0.79, indicating a good level of discriminative ability.

conclusionsThis method's efficacy in discriminating between glioma cells and normal controls underscores the potential of machine learning models in leveraging large datasets for clinical insights.

Indexed as

Brain NeoplasmsGastrointestinal MicrobiomeGliomaMachine LearningAdultFecesFemaleHumansMaleMiddle Agedgliomagut microbiomemachine learning modelsmetagenomic sequencing

Identifiers

PMID40923121
PMCPMC12417957

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.