ReviewCancer pathogenesis and therapy2025
Volatile organic compounds in exhaled breath: Applications in cancer diagnosis and predicting treatment efficacy.
Review in Cancer pathogenesis and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Respirator-integrated continuous gas sampling for broadband optical spectroscopy.Scientific reports · 2026Article
- Article
- Metabolomic profiling of exhaled breath condensate identifies a novel biomarker panel for detecting thyroid and breast cancer.Discover oncology · 2026Article
- [Breath metabolomic characteristics of schizophrenia and their potential for auxiliary diagnosis].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Exhaled Breath Analysis for Head and Neck Cancer Using Fourier-Transform Infrared Spectroscopy: A Feasibility Study for Non-Invasive Screening.Diagnostics (Basel, Switzerland) · 2026Article
- Advanced breath analysis through hierarchical deep convolutional neural network for multi-cancer screening.NPJ digital medicine · 2026Article
- Breath-based lung cancer detection using an ML-driven low-cost sensor array.Scientific reports · 2025Article
- Colorectal Cancer Detection Through Sweat Volatilome Using an Electronic Nose System and GC-MS Analysis.Cancers · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Volatile organic compounds (VOCs) are carbon-based chemicals characterized by high vapor pressure and low boiling points under standard temperature and pressure conditions. VOCs are categorized as exogenous or endogenous, depending on their source. Endogenous VOCs are metabolic byproducts eliminated via respiration. These compounds serve as indicators of human metabolic activity, reflecting differences in tumors compared to normal cell metabolism and the body's response to tumors. Examination of exhaled breath provides a noninvasive approach for assessing metabolic status by comparing VOC levels. Consequently, VOCs are increasingly studied as novel biomarkers for cancer screening, diagnosis, and treatment efficacy prediction. This review outlines VOC production mechanisms, their presence in tumor types, detection methodologies, and their implications for tumor screening, diagnosis, and prognosis. Nonetheless, challenges remain in the utilization of VOCs for cancer diagnosis and predicting treatment outcomes. Furthermore, this review discusses unresolved issues requiring attention to improve malignant tumor assessment, providing insights into their diagnosis, treatment, and prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.