Evidence map›Paper›PMID 40923009›Full record

ArticleBJUI compass2025

Acute kidney injury as a predictor of infectious complications after mini-PCNL.

Angelo Cormio, Daniele Castellani, Domenico De Palma, Ruggiero Fiorella, Runeel Ratnayake, Michele Lotito, Giuseppe Albino, Ugo Giovanni Falagario, Gian Maria Busetto, Carlo Bettocchi and 2 more

Abstract read
In one paragraph

Article in BJUI compass, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Angelo CormioUrology Unit Azienda Ospedaliero-Universitaria delle Marche Ancona Italy.ORCID https://orcid.org/0000-0002-6897-7040
Daniele CastellaniUrology Unit Azienda Ospedaliero-Universitaria delle Marche Ancona Italy.ORCID https://orcid.org/0000-0001-7354-9190
Domenico De PalmaDepartment of Urology and Renal Transplantation, Policlinico Riuniti di Foggia University of Foggia Foggia Italy.
Ruggiero FiorellaDepartment of Urology and Renal Transplantation, Policlinico Riuniti di Foggia University of Foggia Foggia Italy.
Runeel RatnayakeDepartment of Urology and Renal Transplantation, Policlinico Riuniti di Foggia University of Foggia Foggia Italy.
Michele LotitoDepartment of Urology and Andrology, Bonomo Teaching Hospital Andria Italy.
Giuseppe AlbinoDepartment of Urology and Andrology, Bonomo Teaching Hospital Andria Italy.
Ugo Giovanni FalagarioDepartment of Urology and Renal Transplantation, Policlinico Riuniti di Foggia University of Foggia Foggia Italy.
Gian Maria BusettoDepartment of Urology and Renal Transplantation, Policlinico Riuniti di Foggia University of Foggia Foggia Italy.
Carlo BettocchiDepartment of Urology and Renal Transplantation, Policlinico Riuniti di Foggia University of Foggia Foggia Italy.
Giuseppe CarrieriDepartment of Urology and Renal Transplantation, Policlinico Riuniti di Foggia University of Foggia Foggia Italy.
Luigi CormioDepartment of Urology and Renal Transplantation, Policlinico Riuniti di Foggia University of Foggia Foggia Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the incidence, risk factors and clinical consequences of acute kidney injury (AKI) following mini-percutaneous nephrolithotomy (mini-PCNL), with particular focus on its association with postoperative infectious complications. Materials and Methods: A retrospective analysis was conducted on 496 adult patients who underwent mini-PCNL (22 Ch) between February 2020 and April 2025. AKI was defined according to KDIGO criteria as either a ≥ 1.5-fold increase or an absolute increase of ≥0.3 mg/dl in serum creatinine within 72 hours postoperatively. Patients were stratified into AKI and non-AKI groups. Multivariable logistic regression analyses were performed to identify predictors of AKI development and infectious complications. Results: Surgery was done in spinal anaesthesia in all cases. AKI occurred in 45 patients (9.1%). There was no difference in median surgical time (52.5 vs 55.0 minutes, p = 0.33) between groups. There was no difference between the two groups in gender distribution, median age, body mass index, baseline serum creatinine, rates of comorbidities and stone features. Patients with AKI had significantly higher rates of overall postoperative complications (24.4% vs 7.1%, p < 0.001) and longer hospital stays (4 vs 3 days, p < 0.001). Infectious complications were significantly more frequent in the AKI group, with higher median procalcitonin levels (0.21 vs 0.06 ng/ml, p = 0.03). One patient in the AKI group died from sepsis. Multivariable analysis identified previous PCNL (OR 2.51, 95% CI 1.33-4.72, p < 0.01) and higher baseline serum creatinine (OR 2.00, 95% CI 1.07-3.73, p = 0.03) as independent predictors of AKI. AKI was the only independent predictor of infectious complications (OR 3.47, 95% CI 1.04-11.58, p = 0.04). Conclusions: The strong association between AKI and infectious complications, including potential mortality from sepsis, highlights the clinical significance of this underreported complication. Enhanced perioperative monitoring and aggressive management of infectious complications are warranted in patients who develop AKI following mini-PCNL.

Indexed as

acute kidney injuryinfectious complicationskidney calculipercutaneous nephrolithotomy

Identifiers

PMID40923009
PMCPMC12414573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.