ArticleSleep advances : a journal of the Sleep Research Society2025
The CHARMS study: rationale and study protocol for an observational study of sleep and biobehavioral rhythms in older adult couples.
Article in Sleep advances : a journal of the Sleep Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Comparison of Sleep Architecture in Individuals Aged 65 to 80 Years With and Without Mild Cognitive Impairment Using Multi-Channel Sleep Monitoring.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Reflecting on 2025. Anticipating 2026.Sleep advances : a journal of the Sleep Research Society · 2026Article
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5 authors.
Funding
Abstract
Individuals with mild cognitive impairment (MCI) demonstrate cognitive decline without major functional impairment and are at increased risk for developing Alzheimer's disease and related dementias (ADRD). Sleep and biobehavioral rhythm disturbances (disruptions in 24-h oscillations in physiology and behavior, including rest-activity patterns and mealtimes) are more than twice as common among patients with MCI than cognitively intact older adults. Importantly, the consequences of sleep and biobehavioral rhythm disruption in MCI extend beyond the patient, also profoundly affecting the spouse/partner. However, scant research has investigated sleep and biobehavioral rhythms that may contribute to the health and cognitive functioning of individuals with MCI and their partners. The current paper presents the rationale and methods for the Couples Healthy Aging and Rhythms (CHARMS) study, a longitudinal cohort study of sleep and biobehavioral rhythms among older couples in which one partner evidences cognitive decline but is independent in daily functioning. The targeted enrollment goal will consist of 185 couples who meet study eligibility criteria including that one partner shows evidence of cognitive decline but reports being independent in daily activities. This is a longitudinal observational study that includes a baseline assessment, a seven-day at-home naturalistic study protocol, and a two-year follow-up to examine change over time. Findings from this study will advance the understanding of the daily and longitudinal relationships between the individual and couple-level processes in sleep and biobehavioral rhythms that influence the progression of cognitive decline in a population at increased risk for developing ADRD.
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