ArticleCureus2025
Patients on Losartan Have Similar Rates of Manipulation Under Anesthesia After Total Knee Arthroplasty.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Perioperative antihypertensive medication use is associated with no antifibrotic benefit but higher complications and revision rates following shoulder arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Anti-adhesive agents in tendon repair: mechanisms, preclinical evidence, clinical challenges, and future perspectives-a narrative review.Journal of orthopaedic surgery and research · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Patients have identified knee stiffness as a factor contributing to postoperative dissatisfaction after total knee arthroplasty (TKA). Losartan is an angiotensin receptor blocker (ARB) that has demonstrated antifibrotic effects; however, the impact of perioperative losartan on arthrofibrosis after TKA is not well understood. Therefore, the purpose of this study was to determine if losartan exhibits antifibrotic benefits in patients who undergo TKA by decreasing the rates of manipulation under anesthesia (MUA), when compared to patients who are not taking losartan. Methods All patients who underwent primary TKA by fellowship-trained arthroplasty surgeons at a single institution from January 1
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