Evidence map›Paper›PMID 40922779›Full record

ArticleJAACAP open2025

The Presence of Externalizing Diagnoses Increases the Risk of Suicidal Thoughts and Behaviors in Youth Enriched for Early-Onset Depression.

Maida Duncan, Alecia C Vogel, Ashna Ramiah, Rebecca Tillman, Deanna M Barch, Joan Luby, Laura Hennefield

Abstract read
In one paragraph

Article in JAACAP open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maida DuncanWashington University School of Medicine, St. Louis, Missouri.
Alecia C VogelWashington University School of Medicine, St. Louis, Missouri.
Ashna RamiahWashington University School of Medicine, St. Louis, Missouri.
Rebecca TillmanWashington University School of Medicine, St. Louis, Missouri.
Deanna M BarchWashington University School of Medicine, St. Louis, Missouri.
Joan LubyWashington University School of Medicine, St. Louis, Missouri.
Laura HennefieldWashington University School of Medicine, St. Louis, Missouri.

Funding

Suicidality in Young Children: Social and Cognitive Developmental Markers of Risk and ResiliencyK01MH127412 · NIMH · WASHINGTON UNIVERSITY · PI LAURA HENNEFIELD · 2022 to 2026
$897k
NIMH NIH HHS K01 MH127412
6 · The paper itself

Abstract

Objective: To understand the additional impact of externalizing diagnoses and specific externalizing symptoms (eg, impulsivity, irritability) on risk for suicidal thoughts and behaviors (STBs) in a sample of youth enriched for depression. Method: Participants included 219 children from the Pediatric Suicidality Study, which has followed a sample of preschoolers enriched for depression into early adolescence (ages 10-14 years). Semistructured interviews to assess STBs and clinical diagnoses including major depressive disorder (MDD), attention-deficit/hyperactivity disorder (ADHD), and oppositional defiant disorder (ODD) were conducted at preschool age (3-6 years), preadolescence (8-12 years), and 2 years later (10-14 years). Results: Meeting diagnostic criteria for an externalizing disorder at any study time point was significantly associated with experiencing STBs after the preschool period, even when controlling for comorbid depression (66.7% vs 27.6%; χ Conclusion: Youth with comorbid depression and an externalizing disorder or externalizing symptoms of irritability or impulsivity may be at an elevated risk of STBs into early adolescence. These findings highlight the importance of early identification and treatment of externalizing disorders and symptoms in addition to treating depression when managing STBs in this population and provide additional potential treatment targets.

Indexed as

ADHDdepressionODDsuicide

Identifiers

PMID40922779
PMCPMC12414321

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.