Evidence map›Paper›PMID 40922638›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Bioorthogonal Photoactivation of 2-Nitrobenzyl Caged Doxorubicin Anticancer Prodrugs on Gold Nanostars.

Juan José Esteve-Moreno, Andrea Escudero, Oscar Ferreira Silvestre, José Manuel Terrés, Mónica Gorbe, Eva Garrido, Carlos Renero-Lecuna, Judith Langer, María Alfonso, Javier Ibañez and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Juan José Esteve-MorenoInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Andrea EscuderoInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Oscar Ferreira SilvestreCIC biomaGUNE, Basque Research and Technology Alliance (BRTA) Paseo de Miramón 194, Donostia-San Sebastián, 20014, Spain.
José Manuel TerrésInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Mónica GorbeInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Eva GarridoInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Carlos Renero-LecunaCIC biomaGUNE, Basque Research and Technology Alliance (BRTA) Paseo de Miramón 194, Donostia-San Sebastián, 20014, Spain.
Judith LangerCIC biomaGUNE, Basque Research and Technology Alliance (BRTA) Paseo de Miramón 194, Donostia-San Sebastián, 20014, Spain.
María AlfonsoInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Javier IbañezInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Félix SancenónInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Roberto Cao-MilánFacultad de Química, Universidad de La Habana, La Habana, 10400, Cuba.
Luis M Liz-MarzánCIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28040, Spain.
Alba García-FernándezInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Andy Hernández-MontotoInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.
Ramón Martínez-MáñezInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat de València-Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain.

Funding

CIBER-Consorcio Centro de Investigación Biomédica en Red CB06/01/2012ERC Advanced Grant Edison 101052997Generalitat Valenciana CIPROM/2021/007MCIN/AEI Spanish Government PID2021-126304OB-C41MCIN/AEI Spanish Government PID2021-128141OB-C22Provincial Council of Gipuzkoa, Fellows Gipuzkoa Program to O.F.S
6 · The paper itself

Abstract

Bioorthogonal chemistry that can be controlled through near-infrared (NIR) light is a promising route to therapeutics. This study proposes a method to intracellularly photoactivate prodrugs using plasmonic gold nanostars (AuNSt) and NIR irradiation. Two strategies are followed. On one hand, doxorubicin (Dox) masked with a 2-nitrobenzyl carbamate (proDox

Indexed as

Antineoplastic AgentsDoxorubicinGoldMetal NanoparticlesNitrobenzenesProdrugsAnimalsCell Line, TumorHumansInfrared RaysMicePhotochemical ProcessesAntineoplastic AgentsDoxorubicinGoldNitrobenzenesProdrugsbioorthogonal chemistrycancer therapydoxorubicingold nanostarsnear infrared radiationphotocleavable linkersprodrugs photoactivation

Identifiers

PMID40922638
PMCPMC13568838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.