Evidence map›Paper›PMID 40922634›Full record

ArticleEnvironmental science & technology2025

PBDE Flame Retardant Exposure Causes Neurobehavioral and Transcriptional Effects in First-Generation but Not Second-Generation Offspring Fish.

Nicole A McNabb-Kelada, Tara Burke, Saro Jayaraman, Lesley J Mills, Ashley I De La Torre, Madison Silvia, Hannah Schrader, Diane Nacci, Bryan W Clark, Andrew Whitehead

Abstract read
In one paragraph

Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Nicole A McNabb-KeladaDepartment of Environmental Toxicology, University of California Davis, Davis, California 95616, United States.ORCID 0000-0002-6218-4621
Tara BurkeAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, Rhode Island 02882, United States.
Saro JayaramanAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, Rhode Island 02882, United States.
Lesley J MillsAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, Rhode Island 02882, United States.
Ashley I De La TorreDepartment of Environmental Toxicology, University of California Davis, Davis, California 95616, United States.
Madison SilviaAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, Rhode Island 02882, United States.
Hannah SchraderAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, Rhode Island 02882, United States.
Diane NacciAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, Rhode Island 02882, United States.
Bryan W ClarkAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, Rhode Island 02882, United States.
Andrew WhiteheadDepartment of Environmental Toxicology, University of California Davis, Davis, California 95616, United States.ORCID 0000-0002-5457-6449

Funding

ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
NIEHS NIH HHS T32 ES007059
6 · The paper itself

Abstract

Pollution can have lasting effects beyond the exposure period, potentially impacting multiple generations. Polybrominated diphenyl ether (PBDE) flame retardants are widespread, including in oceans, yet their multigenerational impacts remain poorly understood. We investigated whether BDE-99, a ubiquitous PBDE, induces neurobehavioral and molecular effects across generations in the fish

Indexed as

Behavior, AnimalFlame RetardantsGene Expression RegulationHalogenated Diphenyl EthersPrenatal Exposure Delayed EffectsAnimalsBrainEmbryo, NonmammalianFemaleFundulus heteroclitusMale2,2',4,4',5-brominated diphenyl etherFlame RetardantsHalogenated Diphenyl Etherspentabromodiphenyl etherbehaviorecotoxicologymarine toxicologymaternal effectsmultigenerationalneurotoxicologytoxicogenomicstransgenerational

Identifiers

PMID40922634
PMCPMC12424181

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.