Evidence map›Paper›PMID 40922555›Full record

ReviewThe New phytologist2025

Trehalose 6-phosphate - a central regulator at the crossroads of sugar signalling, metabolism, and development.

Franziska Fichtner

Abstract readReview
In one paragraph

Review in The New phytologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Franziska FichtnerInstitute of Plant Biochemistry and Cluster of Excellences on Plant Science (CEPLAS), Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Düsseldorf, 40225, Germany.ORCID https://orcid.org/0000-0002-4508-5437

Funding

Deutsche Forschungsgemeinschaft EXC 2048/1Deutsche Forschungsgemeinschaft FI 2664/2-1Deutsche Forschungsgemeinschaft FI 2664/3-1
6 · The paper itself

Abstract

In mammals, blood sugar levels are tightly controlled by two hormones: insulin and glucagon. In flowering plants, a comparable regulatory mechanism exists, mediated by the sugar-signalling molecule trehalose 6-phosphate (Tre6P). Similar to insulin, Tre6P functions as a signal and negative feedback regulator of sucrose, the main transport sugar in vascular plants. In the model plant Arabidopsis thaliana and likely all other angiosperms, Tre6P is predominantly synthesized in the vasculature, an ideal position to integrate systemic sugar status with whole-plant developmental decision-making. Genes encoding components of Tre6P dephosphorylation and signalling show broader expression patterns suggesting movement and signalling of Tre6P outside the vasculature to coordinate plant metabolism and development.

Indexed as

ArabidopsisCarbohydrate MetabolismPlant DevelopmentSignal TransductionSugar PhosphatesTrehaloseArabidopsis ProteinsGene Expression Regulation, PlantArabidopsis ProteinsSugar PhosphatesTrehalosetrehalose-6-phosphateplant metabolic regulationsingle cell sequencingSnRK1spatial regulation of metabolismsucrosesugar signallingtrehalose 6‐phosphate

Identifiers

PMID40922555
PMCPMC12589705

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.