ArticleThe European journal of neuroscience2025
Maturation of Micturition-Related Neural Circuits That Control Pelvic Visceromotor Functions in Postnatal Rats.
Article in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Maturation of Micturition-Related Neural Circuits That Control Pelvic Visceromotor Functions in Postnatal Rats.The European journal of neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Pelvic visceromotor functions such as micturition are regulated by coordinated autonomic and somatic motor pathways from the central nervous system. The parasympathetic system induces detrusor muscle contraction while the somatic system facilitates relaxation of the external urethral sphincter, ensuring synchronized and efficient bladder emptying during the voiding process. This study explores the relationship between Barrington's nucleus corticotropin-releasing hormone (CRH)-ergic projections and the formation of perineural nets (PNNs) among spinal motoneurons, particularly parasympathetic preganglionic neurons in the intermediolateral nucleus (IML) and Onuf's nucleus during the maturation of the neural circuitry controlling pelvic visceromotor functions. Immunohistochemical analysis revealed CRH expression commenced at postnatal Day 5 (P5) in both the IML and Onuf's nucleus, progressively increasing with age. By P60, CRH expression in Onuf's nucleus showed significant sexual dimorphism, higher in males than in females. In contrast, PNN formation exhibited distinct sex-dependent temporal patterns: Males showed earlier formation in the IML at P25, while females exhibited earlier PNN appearance in Onuf's nucleus at P25. Notably, delayed and reduced formation of PNN compared to somatic motoneurons in previous studies suggests an extended period of synaptic plasticity. This finding suggests a potentially longer and more effective recovery period for pelvic visceromotor system compared to the locomotor system. Furthermore, the observed sex difference in CRH expression and PNN formation in Onuf's nucleus may indicate the involvement of sex hormones. These results contribute to understanding the mechanism and treatment approaches tailored to age, sex, and the recovery of specific function such as micturition following spinal cord injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.