Evidence map›Paper›PMID 40922447›Full record

ArticleBrain and behavior2025

Long-Term Outcomes of Guided Internet-Based Cognitive Behavioral Therapy for Anorexia Nervosa: 3-Year Follow-Up.

Sayo Hamatani, Kazuki Matsumoto, Jumpei Takahashi, Eiji Shimizu, Yoshiyuki Hirano, Yoshifumi Mizuno

Abstract read
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sayo HamataniResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.ORCID https://orcid.org/0000-0001-7847-6381
Kazuki MatsumotoDivision of Clinical Psychology, Kagoshima University Hospital, Research and Education Assembly Medical and Dental Sciences Area, Kagoshima University, Kagoshima, Japan.
Jumpei TakahashiDepartment of Psychiatry, Aoba Municipal Hospital, Chiba, Japan.
Eiji ShimizuResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Yoshiyuki HiranoResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Yoshifumi MizunoResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.

Funding

Japan Society for the Promotion of Science KAKENHI 19J00227Japan Society for the Promotion of Science KAKENHI 23K22256Japan Society for the Promotion of Science KAKENHI 24K21496
6 · The paper itself

Abstract

backgroundGuided internet-based cognitive behavioral therapy (ICBT) provides an accessible alternative treatment for anorexia nervosa (AN), showing initial feasibility and effectiveness in the short term. However, limited research has explored its long-term outcomes in outpatient settings.

objectiveThis study investigated the long-term outcomes and cost-effectiveness of guided ICBT in women with AN who were receiving outpatient treatment.

methodsThis study involved a 3-year follow-up of 11 adult women with AN who received guided ICBT in a previous trial. The Eating Disorder Examination Questionnaire (EDE-Q) and body mass index (BMI) were used as outcomes to assess the severity of AN. A repeated-measures ANOVA was conducted to assess differences in mean outcomes at baseline, post-intervention, and two follow-up time points. The incremental cost-effectiveness ratio was calculated to estimate the cost-effectiveness of this intervention, using quality-adjusted life years (QALYs), derived from the EuroQol 5 Dimension 5-Level (EQ-5D-5L), and costs from publicly available data from the Japanese healthcare system.

resultsFrom baseline, EDE-Q global scores significantly decreased at the 1-year (d = -0.72) and 3-year follow-ups (d = -0.65), while BMI significantly increased at the 1-year (d = 0.66) and 3-year follow-ups (d = 0.98). The estimated incremental cost-effectiveness ratio was notably low, at approximately JPY 111,000 (US$725) per year.

conclusionThese preliminary results suggest that guided ICBT may be effective in the long term for outpatients with AN. Since the threshold has been JPY 5 million in Japan, the current estimated incremental cost-effectiveness ratio suggests that providing guided ICBT to outpatients with AN is likely to be cost-effective.

Indexed as

Anorexia NervosaCognitive Behavioral TherapyInternet-Based InterventionAdultBody Mass IndexCost-Benefit AnalysisFemaleFollow-Up StudiesHumansInternetQuality-Adjusted Life YearsTreatment OutcomeYoung Adultanorexia nervosacognitive behavioral therapyCost‐effectivenessfollow‐up studyguided internet‐based cognitive behavioral therapyJapan

Identifiers

PMID40922447
PMCPMC12417561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.