Trial reportBMC complementary medicine and therapies2025
TriCAM (NCT02976558) - a randomized controlled pilot study of complementary medicine in allogeneic stem cell transplantation to improve quality of life.
Trial report in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02976558 (Prospective Open Randomized Monocentric Two-armed Controlled Clinical Trial in Parallel Groups to Investigate the Influence of Complementary Medicine), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Open Randomized Monocentric Two-armed Controlled Clinical Trial in Parallel Groups to Investigate the Influence of Complementary Medicine (CAM) Interventions on Quality of Life and The Treatment Process of Patients Undergoing Allogenic Stem Cell Transplantation
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAllogeneic stem cell transplantation (aSCT) frequently leads to prolonged impaired quality of life (Qol) and depression. To reduce symptom burden and improve Qol, we implemented a complementary medicine approach (TriCAM).
methodsIn a randomized, controlled clinical trial (NCT02976558), we enrolled 36 patients undergoing aSCT. In addition to standard care, the intervention group received Traditional Chinese Medicine acupuncture (TCMA), music therapy (TaKeTiNa) and active clown role playing. FACT-G was used to assess Qol and HADS-D to asses anxiety and depression. We monitored safety of TCMA as well as typical complications during aSCT.
resultsTCMA did not result in more hematomas, soft tissue infections or bacteriaema. Clinical depression was reduced in the intervention group compared to the control group (p = 0.01). There was a trend towards improvement of Qol over time (P = 0.10) and in reducing aGvHD (P = 0.084) in the intervention group compared to the control group.
conclusionsOur trial is the first to show TCMA to be safe in aSCT. TriCAM showed a trend towards mitigating the loss of QoL and significantly reduced depression in patients undergoing aSCT. The promising results of this pilot study give a first positive signal for safety and efficacy allowing for the design of larger studies to confirm the results and support this particularly vulnerable patient group.
trial registrationClinicalTrials.gov NCT02976558. Registered 29 November 2016.
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