Evidence map›Paper›PMID 40922010›Full record

ArticleBMC research notes2025

Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments.

France Rose, Olta Ibruli, Luca Lichius, Martha Kiljan, Gokcen Gozum, Manoela Iannicelli Caiaffa, Jiali Cai, Li-Na Niu, Jan M Herter, Holger Grüll and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

France Rose *Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany. france.rose@wanadoo.fr.
Olta Ibruli *Department of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Luca LichiusDepartment II of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Martha KiljanCenter for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Gokcen GozumCenter for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Manoela Iannicelli CaiaffaDepartment of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Jiali CaiCenter for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Li-Na NiuCenter for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Jan M HerterCenter for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Holger GrüllInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Reinhard BüttnerInstitute of Pathology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Filippo BeleggiaDepartment of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Graziella BoscoDepartment of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Julie GeorgeDepartment of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Grit S Herter-Sprie *Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Hans Christian Reinhardt *Department of Hematology and Stem Cell Transplantation, Germany 19 Center for Molecular Biotechnology, University Hospital Essen, Essen, Germany.
Katarzyna Bozek *Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSmall cell lung cancer (SCLC) accounts for approximately 15% of lung tumors and is marked by aggressive growth and early metastatic spread. In this study, we used two SCLC mouse models with differing tumor mutation burdens (TMB). To investigate tumor composition, spatial architecture, and interactions with the surrounding microenvironment, we acquired multiplexed images of mouse lung tumors using imaging mass cytometry (IMC). These data build upon a previously published characterization of the mouse model. DATA DESCRIPTION: After tumor detection, mice were assigned to one of five treatment groups. Lung tumor tissues were imaged with a 37-marker IMC panel designed to identify major cell types-tumor, immune, and structural-as well as their functional states. When possible, each tumor was sampled both at its center and border regions. Tumor masks in the form of binary images are provided to delineate tumor areas. Additional metadata include tumor onset and endpoint dates to support downstream correlation or predictive analyses based on the image data. This dataset offers a valuable resource for studying the histological and cellular complexity of SCLC in a genetically controlled mouse model across multiple therapeutic conditions.

Indexed as

Image CytometryLung NeoplasmsSmall Cell Lung CarcinomaTumor MicroenvironmentAnimalsDisease Models, AnimalMiceHyperionIMCMIBI-TOFMouse modelsSCLCTumor microenvironment

Identifiers

PMID40922010
PMCPMC12418687

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.