Evidence map›Paper›PMID 40921971›Full record

ArticleNeuroscience bulletin2026

Nr4a2, A Key Factor Controlling the Development and Functional Maintenance of Forebrain Car3 Neurons.

Yun-Chao Tao, Li Zhao, Qiong Zhang, Xi-Yue Liu, Wei-Tang Liu, Ze-Xuan Li, Ling Hu, Lei Zhang, Jia-Yin Chen, Yu-Qiang Ding and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yun-Chao Tao *State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.ORCID https://orcid.org/0009-0002-5525-8394
Li Zhao *State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Qiong ZhangLaboratory Animal Center, Fudan University, Shanghai, 200032, China.
Xi-Yue LiuState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Wei-Tang LiuShanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, 200032, China.
Ze-Xuan LiLaboratory Animal Center, Fudan University, Shanghai, 200032, China.
Ling HuLaboratory Animal Center, Fudan University, Shanghai, 200032, China.ORCID https://orcid.org/0000-0003-4135-4561
Lei ZhangShanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, 201619, China.ORCID https://orcid.org/0000-0001-7242-5292
Jia-Yin ChenLaboratory Animal Center, Fudan University, Shanghai, 200032, China.
Yu-Qiang DingState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China. dingyuqiang@vip.163.com.ORCID https://orcid.org/0000-0003-1202-4635
Ning-Ning SongLaboratory Animal Center, Fudan University, Shanghai, 200032, China. songnn1982@outlook.com.ORCID https://orcid.org/0000-0001-5206-1911

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nr4a2 (Nurr1) is well known to be vital for midbrain dopaminergic neurons. Recent single-cell RNA analyses reveal that Nr4a2 is expressed in lateral cerebral regions, within neurons named L4/L5/L6 IT Car3. These neurons have attracted intense attention for the molecular mechanisms underlying their development and functions. We classified Car3 neurons into neocortical (Ncx-Car3), claustral (CLA-Car3), and dorsal endopiriform nucleus (dEn-Car3) subpopulations, focusing on the characterization of Ncx-Car3 neurons. These neurons exhibit distinct birthdates and migratory morphologies compared to CLA- and dEn-Car3 neurons, but share a common transcriptomic profile when Nr4a2 is deleted at the embryonic stage or in adulthood. Notably, Nr4a2 misexpression ectopically induces Car3-enriched genes in vivo. Mice lacking Nr4a2 in Car3 ensembles during the embryonic stage or in adulthood display hyperactivity and reduced anxiety-like behaviors. Therefore, our results demonstrate that Nr4a2 is a key factor in regulating the development and functional maintenance of the forebrain Car3 neurons.

Indexed as

NeuronsNuclear Receptor Subfamily 4, Group A, Member 2ProsencephalonAnimalsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNr4a2 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 2AnxietyCar3DevelopmentFunction maintenanceNr4a2

Identifiers

PMID40921971
PMCPMC12950122

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.