Observational studyIndian journal of pediatrics2025
Clinico-Epidemiological Profile and Genetic Characterization of Rotavirus Strains Among Children Aged Under 5 Years Hospitalized with Acute Gastroenteritis in Karnataka, India.
Observational study in Indian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- From Surviving to Thriving: A Protocol-Driven Approach to ELGAN Care.Indian journal of pediatrics · 2025Article
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Authors and funding
14 authors.
Funding
Abstract
objectivesRotavirus is the most frequent cause of severe acute gastroenteritis (AGE) in children aged under 5 y in India. This study aimed to determine the proportion of rotavirus gastroenteritis in children aged under 5 y admitted with AGE and to characterize the circulating genotypes after implementation of rotavirus vaccination within the Universal Immunization Program (UIP) in Karnataka, India.
methodsThis multicenter, cross-sectional observational study included all children aged under 5 y with AGE admitted to four hospitals in Karnataka. Their demographic and clinical characteristics were recorded using a predesigned electronic form. Stool samples were tested for rotavirus using an enzyme-linked immunosorbent assay (ELISA), and all ELISA-positive samples were genotyped using polymerase chain reaction.
resultsOf the 433 children enrolled, 405 had a stool sample tested for rotavirus, of which 97 (23.9%) were positive. The prevalence of rotavirus was highest among children aged 12–23 mo (41.2%), followed by infants aged 24–59 mo (26.8%). Among the 97 rotavirus-positive children, the predominant clinical manifestations were vomiting (95.9%), fever (79.4%), and severe to very severe dehydration (87.6%). G3P[8] (54.2%) was the most common genotype, followed by G1P[6] (17.8%) and G2P[4] (11.5%).
conclusionsOf the children admitted with AGE, 23.9% tested positive for rotavirus, with the highest burden in children aged 12–23 mo. The predominant genotypes were G3P[8], G1P[6], and G2P[4]. Ongoing genotypic surveillance is warranted to assess the impact of rotavirus vaccination on the incidence of rotavirus AGE and circulating rotavirus genotypes in the population to inform rotavirus vaccination strategy.
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