Evidence map›Paper›PMID 40921908›Full record

ReviewImmunologic research2025

Collagen heterogeneity: a barrier and bridge driving tumor immune microenvironment remodeling.

Yewen Xie, Pengyu Chen, Chunjian Qi, Lu Zheng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yewen Xie *Laboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, 213003, China.
Pengyu Chen *Laboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, 213003, China.
Chunjian QiLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, 213003, China. qichunjian@njmu.edu.cn.ORCID 0000-0001-9567-112X
Lu ZhengClinical Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China. zhenglu@suda.edu.cn.

Funding

Changzhou Institute of Technology CZ20230017National Natural Science Foundation of China 32270954Natural Science Foundation of Jiangsu Province BE2023693
6 · The paper itself

Abstract

The tumor microenvironment (TME) is a complex system composed of the extracellular matrix (ECM) and various cell types, with collagen being one of its core components. Collagen heterogeneity profoundly influences tumor progression and the remodeling of the immune microenvironment by regulating tumor cell behavior, signaling pathways, and immune evasion in TME. Different subtypes of collagen significantly affect tumor growth, metastasis, and therapeutic responses by modulating the infiltration and function of immune cells. In "cold" tumors, the immunosuppressive microenvironment is shaped by collagen deposition, fibroblast activation, and the release of immunosuppressive factors. The excessive accumulation of collagen hinders immune cell infiltration and the efficacy of immunotherapy. Now, therapeutic strategies targeting collagen metabolism have shown promise in converting cold tumors into "hot" tumors by reducing collagen deposition and enhancing tumor immunity. This review systematically explores how different collagen subtypes regulate collagen metabolism offering new perspectives for the treatment of cold tumors and laying the theoretical groundwork for future advances in personalized immunotherapy.

Indexed as

CollagenNeoplasmsTumor MicroenvironmentAnimalsExtracellular MatrixHumansImmunotherapyTumor EscapeCollagenCollagen subtypesImmune evasionImmunotherapyMatrix remodelingTumor microenvironment

Identifiers

PMID40921908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.