Evidence map›Paper›PMID 40921879›Full record

ArticleSkeletal radiology2026

Multiparametric assessment of high-grade pediatric soft-tissue sarcomas with anatomic and functional MRI sequences: a retrospective study.

Paulo de Tarso Kawakami Perez, Laura Marie Fayad, Mariana Batista Rosa Pinto, Henrique Manoel Lederman, Eliana Maria Monteiro Caran, Carla Renata Pacheco Donato Macedo, Julio Brandão Guimarães

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Skeletal radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paulo de Tarso Kawakami PerezDepartment of Radiology, Federal University of Sao Paulo (UNIFESP), Napoleão de Barros St, 800, São Paulo, SP, 04024-000, Brazil. paulotkp@gmail.com.
Laura Marie FayadDepartment of Radiology and Radiological Science, The Russel H. Morgan, Johns Hopkins Hospital, Baltimore, MD, USA.
Mariana Batista Rosa PintoDepartment of Radiology, Federal University of Sao Paulo (UNIFESP), Napoleão de Barros St, 800, São Paulo, SP, 04024-000, Brazil.
Henrique Manoel LedermanDepartment of Radiology, Federal University of Sao Paulo (UNIFESP), Napoleão de Barros St, 800, São Paulo, SP, 04024-000, Brazil.
Eliana Maria Monteiro CaranOncology Department, Pediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança (GRAACC), São Paulo, Brazil.
Carla Renata Pacheco Donato MacedoOncology Department, Pediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança (GRAACC), São Paulo, Brazil.
Julio Brandão GuimarãesDepartment of Radiology, Federal University of Sao Paulo (UNIFESP), Napoleão de Barros St, 800, São Paulo, SP, 04024-000, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate multiparametric MRI features of pediatric soft-tissue sarcomas, comparing pre-treatment and post-treatment features, and assessing correlation with clinical outcomes. MATERIALS AND

methodsRetrospective cohort study, including pediatric patients (≤ 18 years) with histologically-confirmed soft-tissue sarcomas who underwent MRI with anatomic and functional sequences in consecutive series. Post-treatment MRI was available for a subset, and features were recorded by two readers. Pre-treatment and post-treatment features were compared using Wilcoxon signed-rank test with Hodges-Lehmann estimator. Inter-reader agreement was assessed with intraclass correlation coefficient, and Mann-Whitney and Cox regression tests were used to correlate the features with clinical outcome.

resultsThere were 27 patients. Pre-treatment we measured tumor size, ADCminimum (mean: 507 × 10-6mm

conclusionFor high-grade pediatric soft-tissue sarcomas, the pre-treatment size is an important prognostic factor, and a reduction in tumor size was observed after treatment, but did not correlate with progression. However, changes to ADC values between pre-treatment and post-treatment MRI correlated with disease progression, suggesting that ADC is a potentially useful biomarker of clinical outcome.

Indexed as

Multiparametric Magnetic Resonance ImagingSarcomaSoft Tissue NeoplasmsAdolescentChildChild, PreschoolDisease ProgressionFemaleFollow-Up StudiesHumansMaleNeoplasm GradingPrognosisProgression-Free SurvivalRetrospective StudiesMultiparametric MRIPediatric oncologyPediatric soft-tissue sarcoma

Identifiers

PMID40921879

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.