ArticleEJNMMI radiopharmacy and chemistry2025
The hydrogenation side-reaction in copper-mediated radiofluorination.
Article in EJNMMI radiopharmacy and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Scaling the production of bromine-76 and bromine-77 labeled poly-ADP-ribose-polymerase-targeted theranostics for preclinical use.EJNMMI radiopharmacy and chemistry · 2026Article
- Illuminating proinflammatory myeloid cells with PET tracers targeting GPR84.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Highlight selection of radiochemistry and radiopharmacy developments by editorial board.EJNMMI radiopharmacy and chemistry · 2026Article
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Authors and funding
6 authors.
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Abstract
backgroundCopper-mediated radiofluorination (CMRF) is a breakthrough in
resultsThe present work investigates the factors influencing the rate of the hydrogenation reaction as well as the source of hydrogen in the CMRF by use of model precursors bearing -B(OH)
conclusionThis study identifies reaction parameters that influence hydrogenation side reactions in CMRF, enabling high RCC with minimal HSP formation. The optimal reaction conditions include low temperature, short reaction time, and minimal amount of precursor, copper, and ideally no base and alcohols as solvents. Among the evaluated precursors, -BEpin afforded the lowest HSP formation, while -B(OH)
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