Evidence map›Paper›PMID 40921843›Full record

ArticleNature methods2025

Scvi-hub: an actionable repository for model-driven single-cell analysis.

Can Ergen, Valeh Valiollah Pour Amiri, Martin Kim, Ori Kronfeld, Aaron Streets, Adam Gayoso, Nir Yosef

Abstract read
In one paragraph

Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Can Ergen *Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. ergenbehr@gmail.com.ORCID http://orcid.org/0000-0002-3096-2927
Valeh Valiollah Pour Amiri *Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.
Martin KimCenter for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0009-0000-2115-6213
Ori KronfeldDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Aaron StreetsCenter for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-3909-8389
Adam GayosoCenter for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. adamgayoso@berkeley.edu.ORCID http://orcid.org/0000-0001-9537-0845
Nir YosefCenter for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. nir.yosef@weizmann.ac.il.ORCID http://orcid.org/0000-0001-9004-1225

Funding

OPTICAL, FLUIDIC, AND MOLECULAR TECHNOLOGIES FOR SINGLE-CELL OMICSR35GM124916 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Aaron Streets · 2017 to 2026
$3.4M
NIGMS NIH HHS R35 GM124916
6 · The paper itself

Abstract

The growing availability of single-cell omics datasets presents new opportunities for reuse, while challenges in data transfer, normalization and integration remain a barrier. Here we present scvi-hub: a platform for efficiently sharing and accessing single-cell omics datasets using pretrained probabilistic models. It enables immediate execution of fundamental tasks like visualization, imputation, annotation and deconvolution on new query datasets using state-of-the-art methods, with massively reduced storage and compute requirements. We show that pretrained models support efficient analysis of large references, including the CZI CELLxGENE Discover Census. Scvi-hub is built within the scvi-tools open-source environment and integrated into scverse. Scvi-hub offers a scalable and user-friendly framework for accessing and contributing to a growing ecosystem of ready-to-use models and datasets, thus putting the power of atlas-level analysis at the fingertips of a broad community of users.

Indexed as

Computational BiologySingle-Cell AnalysisSoftwareHumansModels, Statistical

Identifiers

PMID40921843
PMCPMC12446071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.