ArticleNature immunology2025
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis.
Abstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dysfunctional adipose tissue-lymphatic crosstalk in obesity.Nature reviews. Endocrinology · 2026Review
- The crosstalk between lymphatic endothelial cells and immune cells in Physiological and Pathological conditions.Cellular and molecular life sciences : CMLS · 2026Review
- Flow-based imaging reveals dissociated monocyte adhesion and transmigration patterns between TNF-α and diabetes-induced vascular inflammation.Frontiers in immunology · 2026Article
Corrections and comments
- Update of
Authors and funding
16 authors.
Emma C ErlichDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-2584-1407
Quazim A AlayoDivision of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5524-7105
Ayoung KimDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Jichang HanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Rachel L MintzDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Christopher G HuckstepDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0009-0004-8066-6343
Heather S RuizDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Rachael L FieldDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0009-0003-1717-9756
Taylor J DunningDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Leila S SalehDepartment of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Mark H HoofnagleDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Alexei V TumanovDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Sciences Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-6042-0152
Farshid GuilakDepartment of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-7380-0330
Jonathan R BrestoffDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-7018-7400
Rafael S CzepielewskiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-2475-3838
Gwendalyn J RandolphDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. gjrandolph@wustl.edu.ORCID http://orcid.org/0000-0001-9045-1195
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MThe protein tyrosine kinase SYK drives innate immune responses against Alzheimer's DiseaseP01AG078106 · NIA · WASHINGTON UNIVERSITY · PI Jonathan Kipnis · 2022 to 2026
$18.4MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6MTRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8MCLINICAL/LABORATORY TRAINING ACADEMIC GASTROENTEROLOGYT32DK007130 · NIDDK · WASHINGTON UNIVERSITY · PI MATTHEW AARON CIORBA · 1986 to 2026
$8.3MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MTRAINING IN THE IMMUNOLOGY OF RHEUMATIC DISEASEST32AR007279 · NIAMS · WASHINGTON UNIVERSITY · PI Megan Anne Cooper, Deborah J Lenschow · 1986 to 2026
$6.0MPediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MSkeletal Disorders Training ProgramT32AR060719 · NIAMS · WASHINGTON UNIVERSITY · PI Roberto Civitelli · 2011 to 2026
$4.6MAmerican Gastroenterological Association (AGA) P25-01816Burroughs Wellcome Fund (BWF) 1019648Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP220470Crohn's and Colitis Foundation (Crohn's & Colitis Foundation) 938100NCI NIH HHS F30 CA281124NCI NIH HHS K00 CA264434NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI168044NIAID NIH HHS R03 AI068044NIAID NIH HHS R37 AI049653NIAID NIH HHS T32 AI007163NIAID NIH HHS U01 AI163064NIAMS NIH HHS P30 AR073752NIAMS NIH HHS P30 AR074992NIAMS NIH HHS T32 AR007279NIAMS NIH HHS T32 AR060719NIA NIH HHS P01 AG078106NIDDK NIH HHS DP1 DK130660NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK119147NIDDK NIH HHS T32 DK007130NIDDK NIH HHS T32 DK077653U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) K00CA264434U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI168044U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI007163U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01AI163064U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DP1DK130660U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) T32DK007130U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) T32DK077653U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) F30CA281124U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) DP5028125
Abstract
Crohn's disease pathology is modeled in TNF
Indexed as
B-LymphocytesCrohn DiseaseIleitisTumor Necrosis Factor-alphaAnimalsDisease Models, AnimalIleumMiceMice, Inbred C57BLMice, KnockoutTumor Necrosis Factor-alpha
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.