SynthesisMolecular psychiatry2025
Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.
Synthesis in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurobiological insights into perinatal depression: a multi-dimensional integration of brain structure, function, and metabolism.Frontiers in psychiatry · 2026Pooled it
- Parental brain responses to own and unknown children's emotional facial expressions: An fMRI study.Cognitive, affective & behavioral neuroscience · 2026Article
- Cell-type and spatiotemporal transcriptional signatures of white matter morphometric similarity network alterations in major depressive disorder.Psychological medicine · 2026Article
- An exploratory study of glycemic biomarkers and rTMS treatment outcomes in treatment-resistant depression.BMC psychiatry · 2026Article
- Peripheral Blood Transcriptomic Features Distinguishing Postpartum Depression from Major Depressive Disorder and Healthy Postpartum Controls.International journal of women's health · 2026Article
- Psychedelic therapy and postpartum depression: priorities and prospects.Therapeutic advances in psychopharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundPeripartum depression (PPD) is a form of major depressive disorder (MDD) that begins during the peripartum period and poses a significant mental health challenge affecting 10 to 29% of women.
objectiveThis systematic review and multimodal activation likelihood estimation (ALE) meta-analysis explored the distinct structural, functional, and metabolic features of the PPD brain as compared to female non-peripartum MDD.
methodsFor this purpose, we conducted a comprehensive literature search in PubMed, Embase and PsycINFO databases to identify peer-reviewed original studies investigating the neural correlates associated with PPD or fMDD.
resultsForty-five studies in PPD and 55 in fMDD were included in the qualitative synthesis. From these, 25 PPD and 32 fMDD studies were included in the meta-analysis. Both shared and distinct neural underpinnings of PPD and fMDD were observed. Specifically, we found alterations in the cognitive control, salience and default mode networks for both PPD and fMDD, although with reversed structural and functional activity patterns in the insula, amygdala, precentral gyrus and precuneus.
conclusionsThese findings support the consistent pattern of dysregulation associated with emotional regulation, cognition and maternal caregiving in women with PPD, as well as possible differential sensitivity to hormonal influences, highlighting the need for targeted interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.