Evidence map›Paper›PMID 40921786›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Neurodevelopmental considerations for transcranial magnetic stimulation trials in youth.

Christine A Conelea, Alana Lieske

Abstract readReview
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. The puzzle of heterogeneity: an introduction to part II.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Trajectories of mental health and mental illness: where we are now and where we go next.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christine A ConeleaDepartment of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA. cconelea@umn.edu.
Alana LieskeDepartment of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0009-0001-7147-900X

Funding

Transcranial Magnetic Stimulation to Augment Exposure and Response Prevention for Pediatric OCDR61MH133666 · NIMH · EMMA PENDLETON BRADLEY HOSPITAL · PI BENITO, KRISTEN G, CONELEA, CHRISTINE A · 2023 to 2024
$2.4M
Transcranial Magnetic Stimulation to Augment Behavior Therapy for TicsR61MH123754 · NIMH · UNIVERSITY OF MINNESOTA · PI CONELEA, CHRISTINE A · 2020 to 2020
$1.2M
Transcranial Magnetic Stimulation to Augment Behavior Therapy for TicsR33MH123754 · NIMH · UNIVERSITY OF MINNESOTA · PI Christine A Conelea · 2025 to 2026
$1.2M
NIMH NIH HHS R33 MH123754NIMH NIH HHS R61 MH123754NIMH NIH HHS R61 MH133666
6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for neuropsychiatric disorders that shows initial efficacy, safety, and tolerability in adolescents with treatment-resistant depression. As research expands to clinical trials testing rTMS in youth with other diagnoses and at younger ages, it is important to consider how neurodevelopmental factors might moderate or mediate rTMS effects and factor this into clinical trial design. In the current paper, we review how key domains of neurodevelopment may interact with rTMS, including neuroanatomy, neural circuit network topography, neuroplasticity, hormones, state-dependent effects, and psychosocial development. We also highlight approaches that can be taken in trials to enhance developmental adaptations of rTMS while also balancing ethical considerations, safety, feasibility, and tolerability. Future directions for research as we move into the "efficacy era" of pediatric rTMS research are discussed.

Indexed as

BrainClinical Trials as TopicDepressive Disorder, Treatment-ResistantTranscranial Magnetic StimulationAdolescentChildHumansNeuronal Plasticity

Identifiers

PMID40921786
PMCPMC12618615

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.