ArticleAesthetic plastic surgery2026
Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study.
Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Regenerative Skin Remodeling by a Dual Hyaluronic Acid Hybrid Complex in Multimodal Preclinical Models.International journal of molecular sciences · 2026Article
- Hybrid Cooperative Complexes of Low- and High-Molecular-Weight Hyaluronic Acid in Aesthetic Medicine.Pharmaceuticals (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies of Profhilo
aimsThe efficacy and safety of Profhilo PATIENTS/
methodsPatients were treated with Profhilo
resultsOf 30 enrolled Chinese females (aged 38.0-60.0 years), outcome data were analyzed for 28 and 26 patients at Weeks 0-4 and follow-up, respectively, aside from skin hydration (N = 8 and N = 6, respectively). Treatment led to a FVLS (P = 0.0150), WSRS (P = 0.0057), and R3 ("tiring effect" of the skin; P = 0.0424) decrease over time, but pairwise time point comparisons for these measures were not significant (NS). A trend toward a decrease in F1 (elasticity) over time occurred but was NS. A statistically significant improvement in superficial skin hydration and TEWL occurred over time (P = 0.0010 and P = 0.0055, respectively) and, specifically, at Week 12 versus baseline (P = 0.0034 and P = 0.0029, respectively). Patients reported "good" product tolerability.
conclusionsProfhilo LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.