Evidence map›Paper›PMID 40921768›Full record

ArticleInternational journal of obesity (2005)2025

A U-shaped relationship between body mass index and the risk of elevated liver stiffness in older people: evidence from the 5-year retrospective cohort study.

Liang Lv, Lu Long, Yue Zheng, Nan Yang, Jinyu Xiao, Tianpei Ma, Xin Chen, Xinyang Dui, Xiaoxue Liu, Tao Zhang and 3 more

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Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

13 authors.

Liang Lv *West China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0003-2703-4190
Lu Long *West China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Yue ZhengWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Nan YangWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Jinyu XiaoWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Tianpei MaWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xin ChenWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xinyang DuiWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xiaoxue LiuWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Tao ZhangWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Huan ZhouDepartment of Health Behavior and Social Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Juan LiaoWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China. Juanliao@scu.edu.cn.ORCID 0000-0002-2446-9861
Jiayuan LiWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China. lijiayuan@scu.edu.cn.ORCID 0000-0002-6965-8877

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between body mass index (BMI) and liver stiffness in older people remains unclear. This study aimed to examine the association between BMI and the risk of elevated liver stiffness in older people.

methods2736 participants from the West China Health and Aging Cohort Study (WCHAC) were included in the present study. Liver stiffness was assessed using transient elastography (TE). The association of the 5-year average BMI level with elevated liver stiffness risk was estimated using multinomial logistic regression. The group-based trajectory model (GBTM) was applied to identify BMI trajectories. Additionally, restricted cubic spline analysis was conducted to explore the dose-response association between BMI and the risk of elevated liver stiffness.

resultsParticipants in the second BMI quartile (21.93-23.58) had the lowest prevalence of elevated liver stiffness, and then the risk increased with higher BMI quartiles (BMI Q4 vs. Q2, OR = 2.05, 95% CI: 1.37-3.11 and Q5 vs. Q2, OR = 2.82, 95% CI: 1.78-4.39). There were five BMI trajectories over the five-year period: low-normal-weight stable (7.42%), moderate-normal-weight stable (29.10%), low-level-overweight stable (36.22%), high-level-overweight stable (20.32%) and stable obesity (6.94%). Participants in the moderate-normal-weight stable group had the lowest prevalence of elevated liver stiffness. Compared with this group, the adjusted ORs (95% CI) elevated liver stiffness prevalence were 2.02 (1.39-2.97) for the high-level-overweight stable, and 2.83 (1.72-4.64) for the group of people with stable obesity. Dose-response analysis revealed a U-shaped relationship between BMI and elevated liver stiffness risk, suggesting an optimal BMI range of 21.8-24.3 kg/m² for older people to minimize elevated liver stiffness risk.

conclusionsOur study elucidated the U-shaped relationship between BMI and the risk of elevated liver stiffness as measured by TE, and the optimal BMI range from 21.8 to 24.3 kg/m

Indexed as

Body Mass IndexLiverObesityAgedChinaCohort StudiesElasticity Imaging TechniquesFemaleHumansMaleMiddle AgedRetrospective StudiesRisk Factors

Identifiers

PMID40921768

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.