ArticleOpen heart2025
High-sensitivity troponin T as a rule-out marker for myocardial inflammation detectable by CMR imaging.
Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Outcomes by cardiovascular magnetic resonance in patients with clinically suspected myocardial inflammation.The international journal of cardiovascular imaging · 2026Article
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14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute myocarditis is a potentially life-threatening cardiac condition and immediate assessment of this disease is imminent. While laboratory tests, electrocardiography or transthoracic echocardiography can provide indirect signs for the presence of acute myocarditis, cardiac magnetic resonance (CMR) imaging enables direct visualisation of myocardial inflammation and confirms the diagnosis.Since there is limited accessibility to CMR, the goal of this study was to evaluate the sensitivity and specificity of an elevation of established biomarkers for the diagnosis of myocarditis and to define a specific rule-out threshold for deferring CMR.
methods244 consecutive patients with clinical suspicion of acute myocarditis underwent comprehensive CMR imaging. CMR data and laboratory parameters were retrospectively analysed.
resultsBased on the CMR results, the diagnosis of acute myocarditis was confirmed in 72 individuals. Significant differences regarding age, cardiac function and biomarker levels were present between these groups. Receiver operating characteristics analysis revealed high-sensitivity troponin T (hsTNT) with high sensitivity and specificity for the result of the CMR examination. With a negative predictive value of 0.96 and a sensitivity of 0.92, a hsTNT cut-off of 18 pg/mL was defined as a safe rule-out value for suspected myocarditis.
conclusionsCMR imaging is the gold standard for the non-invasive confirmation of acute myocarditis. However, in this cohort, patients with a hsTNT level of ≤18 pg/mL have a very low likelihood of acute myocarditis, suggesting that CMR may not be necessary to exclude the diagnosis.
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