ArticleDevelopmental biology2025
Injury-induced Neuregulin-EGFR signaling from muscle mobilizes stem cells for whole-body regeneration in acoels.
Article in Developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A neuregulin-like ligand and EGF receptor underpinFrontiers in cellular and infection microbiology · 2026Article
Corrections and comments
- Update of
Authors and funding
5 authors.
Funding
Abstract
The activation of progenitor cells near wound sites is a common feature of regeneration across species, but the conserved signaling mechanisms responsible for this step in whole-body regeneration are still incompletely understood. The acoel Hofstenia miamia undergoes whole-body regeneration using Piwi + pluripotent adult stem cells (neoblasts) that accumulate at amputation sites early in regeneration. The EGFR signaling pathway has broad roles in controlling proliferation, migration, differentiation, and cell survival across metazoans. Using candidate RNAi screening, we identify the Hofstenia EGFR egfr-1 and Neuregulin nrg-1 genes as essential for blastema formation. Structure prediction of NRG-1 and EGFR-1 proteins suggests these factors interact directly. After amputation injuries, nrg-1 expression is induced in body-wall muscle cells at the wound site by 6 h and localizes to the tip of the outgrowing blastema by 24 h and sustains for several days, while egfr-1 is broadly expressed, including in muscle and neoblasts. The early phase of nrg-1 expression occurs at incision sites that repair through wound healing while the late phase is specific to blastema formation. Under nrg-1(RNAi) and egfr-1(RNAi) conditions that impair blastema formation, animals still undergo the earliest responses to injury to activate expression of the Early Growth Response transcription factor egr. In addition, RNAi of nrg-1 only after amputation results in regeneration failure, indicating regeneration requires new nrg-1 expression. nrg-1(RNAi) and egfr-1(RNAi) animals possess Piwi+ and H3P + mitotic neoblasts which hyperproliferate normally after amputation, but these cells fail to accumulate at the wound site. Therefore, muscle provides a source for Neuregulin-EGFR signaling after injury and is necessary for the mobilization of proliferative progenitors to enable blastema outgrowth for whole-body regeneration in Hofstenia. These results indicate a shared functional requirement for muscle signaling to enable regeneration between planarians and acoels across 550 million years of evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.