Evidence map›Paper›PMID 40921204›Full record

ArticleJournal of the American Chemical Society2025

Kinetic Locking of pH-Sensitive Complexes for Mechanically Responsive Polymer Networks.

Stephen J K O'Neill, Yuen Cheong Tse, Zehuan Huang, Xiaoyi Chen, Jade A McCune, Oren A Scherman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephen J K O'NeillMelville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Yuen Cheong TseMelville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Zehuan HuangMelville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.ORCID 0000-0003-4111-7064
Xiaoyi ChenMelville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.ORCID 0000-0001-9833-1390
Jade A McCuneMelville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Oren A SchermanMelville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.ORCID 0000-0001-8032-7166

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Achieving sensitive and reversible responsivity over physiologically relevant pH ranges (4.5-7.5) remains of great interest for the design of next-generation autonomous drug delivery devices. Developing molecular interactions that are responsive within this pH range would enable targeted drug delivery at tumor sites or within inflamed or arthritic joints, where these changes in pH occur. Here, we demonstrate pH-responsive molecular interactions by the kinetic locking of host-guest complexes. Employing these complexes as dynamic crosslinks within polymer networks gives rise to materials with highly pH-responsive mechanical and viscoelastic properties. These systems further exhibit pH-dependent release of cargo, offering a self-responsive approach toward targeted drug delivery.

Identifiers

PMID40921204
PMCPMC12447493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.